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HNF1A Antibody

CAT: 0013-GTR18574509Size: 7 mLDry Ice: NoHazardous: No
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CAT#:0013-GTR18574509Size:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HNF1A is a transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. [UniProt]
UniProt
P20823
Reactivity
Human
Immunogen
A portion of amino acids 214-339 from the human protein was used as the immunogen for the HNF1A antibody.
Clonality
Monoclonal
Clone
HPTF1A-1
Conjugation
Unconjugated
Purification
Protein G affinity chromatography
Dilution
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
The stated application concentrations are suggested starting points. Titration of the HNF1A antibody may be required due to differences in protocols and secondary/substrate sensitivity.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
Prediluted in 1X PBS, 0.1 mg/ml rAlbumin, 0.05% sodium azide; For IHC use only
Isotype
Mouse IgG1, kappa

UniProtKB · P20823

Hepatocyte nuclear factor 1-alpha

HNF1A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P20823
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HNF1A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
HNF-1-alpha, HNF-1A
EC number
—
Processing
—
Secondary accessions
A0A0A0MQU7, A5Z2R8, E0YMJ5, E0YMK0, E0YMK1, E2I9R4, E2I9R5, F5H5U3, Q2M3H2, Q99861
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Disease

Diabetes mellitusDisease variant

Domain

Homeobox

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Cellular component

Nucleus

Biological process

TranscriptionTranscription regulation

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