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Izonsteride

CAT: 0804-HY-106129-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-106129-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Izonsteride (Compound LY320236) is an inhibitor of 5α-reductase (IC50 = 11.6 nM for type I; 7.37 nM for type II) . LY320236 inhibits the activity of steroid 5α-reductase, preventing the conversion of testosterone (T) to dihydrotestosterone (DHT) . LY320236 can significantly inhibit the growth of LNCaP tumors in thymic mice without exhibiting obvious host toxicity[1].
CAS Number
176975-26-1
Product Name Alternative
LY 320236
UNSPSC
12352005
Target
5 alpha Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/izonsteride.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12C3=CC=C(SC4=NC5=C(CC)C=CC=C5S4)C=C3CC[C@@]1([H])N(C(CC2)=O)C
Molecular Formula
C24H26N2OS2
Molecular Weight
422.61
References & Citations
[1]McNulty AM, et al. Kinetic analysis of LY320236: competitive inhibitor of type I and non-competitive inhibitor of type II human steroid 5alpha-reductase. J Steroid Biochem Mol Biol. 2000 Jan-Feb;72 (1-2) :13-21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
M34293-01Izonsteride

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