Globomycin

• UNSPSC Description:

  Globomycin is a lipopeptide antibiotic and a signal peptidase II (LspA) inhibitor. Globomycin inhibits processing of the prolipoprotein by binding irreversibly to the peptidase. Globomycin has toxic for the mollicute Spiroplasma melliferum with a MIC in the range 6.25-12.5 μM[1][2].

• Target Antigen:

  Antibiotic; Bacterial

• Type:

  Peptides

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/globomycin.html

• Purity:

  99.0

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)C[C@@](N(C([C@@H]([C@H](OC(CNC1=O)=O)CCCCCC)C)=O)C)([H])C(N[C@@](C(N[C@H](C(N[C@@]1([H])[C@@H](O)C)=O)CO)=O)([H])[C@H](C)CC)=O

• Molecular Weight:

  655.82

• References & Citations:

  [1]Béven L, et al. Inhibition of spiralin processing by the lipopeptide antibiotic globomycin. Curr Microbiol. 1996 Nov;33(5):317-22.|[2]Parthasarathy S, et al. Organophosphate Hydrolase Is a Lipoprotein and Interacts with Pi-specific Transport System to Facilitate Growth of Brevundimonas diminuta Using OP Insecticide as Source of Phosphate. J Biol Chem. 2016 Apr 1;291(14):7774-85.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  67076-74-8