Corticosterone

• Description:

  Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala) . Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect[1][2][3][4].

• Product Name Alternative:

  17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B

• UNSPSC:

  12352211

• Hazard Statement:

  H317

• Target:

  Endogenous Metabolite; Glucocorticoid Receptor; iGluR

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Endocrinology; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Corticosterone.html

• Purity:

  99.77

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |Ethanol : 14.29 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

• Smiles:

  C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O

• Molecular Formula:

  C21H30O4

• Molecular Weight:

  346.47

• Precautions:

  H317

• References & Citations:

  [1]Elftman MD, et al. Corticosterone impairs dendritic cell maturation and function. Immunology. 2007 Oct;122 (2) :279-90. |[2]Schaaf MJ, et al. Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone. Brain Res. 1998 Nov 30;813 (1) :112-20. |[3]Fahlke C, et al. Involvement of corticosterone in the modulation of ethanol consumption in the rat. Alcohol. 1994 May-Jun;11 (3) :195-202.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 3

• Isoform:

  AMPA Receptor; Human Endogenous Metabolite

• CAS Number:

  [50-22-6]