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Corticosterone

CAT: 0804-HY-B1618-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1618-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala) . Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect[1][2][3][4].
CAS Number
50-22-6
Product Name Alternative
17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B
UNSPSC
12352211
Hazard Statement
H317
Target
Endogenous Metabolite; Glucocorticoid Receptor; iGluR
Type
Natural Products
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Endocrinology; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Corticosterone.html
Purity
99.77
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 14.29 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Molecular Formula
C21H30O4
Molecular Weight
346.47
Precautions
H317
References & Citations
[1]Elftman MD, et al. Corticosterone impairs dendritic cell maturation and function. Immunology. 2007 Oct;122 (2) :279-90. |[2]Schaaf MJ, et al. Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone. Brain Res. 1998 Nov 30;813 (1) :112-20. |[3]Fahlke C, et al. Involvement of corticosterone in the modulation of ethanol consumption in the rat. Alcohol. 1994 May-Jun;11 (3) :195-202.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 3
Isoform
AMPA Receptor; Human Endogenous Metabolite

Alternative Products

CatalogName
B7469-5.1Corticosterone

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