Leonurine

• Description :

  Leonurine is an alkaloid isolated from Leonurus artemisia, with anti-oxidative and anti-inflammatory.

• CAS Number :

  [24697-74-3]

• Product Name Alternative :

  SCM-198

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Autophagy

• Type :

  Natural Products

• Related Pathways :

  Autophagy

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Leonurine.html

• Purity :

  99.86

• Solubility :

  DMSO : 30.3 mg/mL (ultrasonic; adjust pH to 3 with 1 M HCl) |H2O : < 0.1 mg/mL

• Smiles :

  O=C(OCCCCNC(N)=N)C1=CC(OC)=C(O)C(OC)=C1

• Molecular Formula :

  C14H21N3O5

• Molecular Weight :

  311.33

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Jiang T, et al. Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Pparγ/Lxrα Signaling Pathway-Dependent Manner. Cell Physiol Biochem. 2017;43 (4) :1703-1717.|[2]Zhang L, et al. Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signaling pathway. Biomed Pharmacother. 2018 Dec 7;110:571-581.|[3]Hu ZC, et al. Inhibition of PI3K/Akt/NF-κB signaling with leonurine for ameliorating the progression of osteoarthritis: In vitro and in vivo studies. J Cell Physiol. 2018 Nov 11.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported