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Lipstatin

CAT: 0804-HY-N2330-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2330-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lipstatin is a pancreatic lipase inhibitor (IC50=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin ([1][2].
CAS Number
96829-59-3
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Lipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lipstatin.html
Purity
80.0
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
CC(C)C[C@@H](C(O[C@H](C[C@@H]([C@@H]1CCCCCC)OC1=O)C/C=C\C/C=C\CCCCC)=O)NC=O
Molecular Formula
C29H49NO5
Molecular Weight
491.70
Precautions
H315, H319, H335
References & Citations
[1]Weibel E K, et al. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini I. Producing organism, fermentation, isolation and biological activity[J]. The Journal of antibiotics, 1987, 40 (8) : 1081-1085.|[2]Hochuli E, et al. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. II. Chemistry and structure elucidation. J Antibiot (Tokyo) . 1987 Aug;40 (8) :1086-91.|[3]Weibel EK, et al. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity. J Antibiot (Tokyo) . 1987 Aug;40 (8) :1081-5.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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