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PP58

CAT: 0804-HY-18622-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-18622-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PP58 is a pyrido[2,3-d]pyrimidine-based compound that inhibits PDGFR, FGFR and Src family activities with nanomolar IC50 values.
CAS Number
212391-58-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
FGFR; PDGFR; Src
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PP58.html
Concentration
10mM
Purity
98.70
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
NCCOC1=CC=C(NC(N=C2N3C)=NC=C2C=C(C4=C(Cl)C=CC=C4Cl)C3=O)C=C1
Molecular Formula
C22H19Cl2N5O2
Molecular Weight
456.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Wissing J, et al. Chemical Proteomic Analysis Reveals Alternative Modes of Action for Pyrido[2,3-d]pyrimidine Kinase Inhibitors. Mol Cell Proteomics. 2004 Dec;3 (12) :1181-93.|[2]Blencke S, et al. Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors. Chem Biol. 2004 May;11 (5) :691-701.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDGFR

Chemical Information

2-[4-(2-Aminoethoxy)anilino]-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7-one
CAS Number212391-58-7
PubChem CID5327904
IUPAC Name2-[4-(2-aminoethoxy)anilino]-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7-one
Molecular FormulaC22H19Cl2N5O2
Molecular Weight456.3
XLogP3.9
Topological Polar Surface Area93.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count31
Formal Charge0
Complexity648
SMILES
CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC=C3Cl)Cl)NC4=CC=C(C=C4)OCCN
InChI
InChI=1S/C22H19Cl2N5O2/c1-29-20-13(11-16(21(29)30)19-17(23)3-2-4-18(19)24)12-26-22(28-20)27-14-5-7-15(8-6-14)31-10-9-25/h2-8,11-12H,9-10,25H2,1H3,(H,26,27,28)
InChIKey
MAXZESONWXTISA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-[4-(2-Aminoethoxy)anilino]-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7-one
CAS: 212391-58-7
CID: 5327904
Formula: C22H19Cl2N5O2
MW: 456.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight456.3
XLogP33.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass455.0915803
Monoisotopic Mass455.0915803
Topological Polar Surface Area93.4 Ų
Heavy Atom Count31
Formal Charge0
Complexity648
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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L1565-02CLck (Lck p56, Lymphocyte Cell Specific Protein Tyrosine Kinase, LSK, Oncogene lck, P56 LCK, pp58 lck, Proto-oncogene Tyrosine Protein Kinase LCK, T cell Specific Protein Tyrosine Kinase, T lymphocyte Specific Protein Tyrosine Kinase p56lck, Tyrosine-protein Kinase Lck, YT16)

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