Muramyl dipeptide

• Description :

  Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is a NLRP1 agonist[1][2].

• Product Name Alternative :

  MDP

• UNSPSC :

  12352211

• Hazard Statement :

  H315, H319

• Target :

  NOD-like Receptor (NLR) ; p38 MAPK

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; MAPK/ERK Pathway

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/muramyl-dipeptide.html

• Concentration :

  10mM

• Purity :

  98.0

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

• Smiles :

  CC(N[C@@H](C=O)[C@H]([C@H](O)[C@H](O)CO)O[C@H](C)C(N[C@@H](C)C(N[C@@H](C(N)=O)CCC(O)=O)=O)=O)=O

• Molecular Formula :

  C19H32N4O11

• Molecular Weight :

  492.48

• Precautions :

  H315, H319

• References & Citations :

  [1]Park OJ, et al. Muramyl Dipeptide, a Shared Structural Motif of Peptidoglycans, Is a Novel Inducer of Bone Formation through Induction of Runx2. J Bone Miner Res. 2017 Jul;32 (7) :1455-1468.|[2]V Kaushal, et al. Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation. Cell Death Differ. 2015 Oct;22 (10) :1676-86.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• Isoform :

  NLRP1; p38 MAPK

• CAS Number :

  [53678-77-6]