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Floctafenine

CAT: 0804-HY-A0259-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0259-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Floctafenine, a nonsteroidal anti-inflammatory agent (NSAID), acts as an effective analgesic agent[1][2]. Floctafenine is an inhibitor of COX-1 and COX-2 activities in vitro, showing a slightly higher potency towards COX-I. Floctafenine is used for the research of short term pain research[3].
CAS Number
23779-99-9
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/floctafenine.html
Purity
94.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OCC(O)CO)C1=CC=CC=C1NC2=CC=NC3=C(C(F)(F)F)C=CC=C23
Molecular Formula
C20H17F3N2O4
Molecular Weight
406.36
Precautions
H315, H319, H320
References & Citations
[1]P Giuseppe, et al. Floctafenine: a valid alternative in patients with adverse reactions to nonsteroidal anti-inflammatory drugs. Ann Allergy Asthma Immunol. 1997 Jan;78 (1) :74-8.|[2]Gehan Hegazy Hegazy, et al. Synthesis of some floctafenine derivatives of expected anti-inflammatory/analgesic activity. Arch Pharm (Weinheim) . 2005 Aug;338 (8) :378-84.|[3]R Maenthaisong, et al. Clinical pharmacology of cyclooxygenase inhibition and pharmacodynamic interaction with aspirin by floctafenine in Thai healthy subjects.Int J Immunopathol Pharmacol. Apr-Jun 2013;26 (2) :403-17.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2

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