Ospemifene

• Description:

  Ospemifene (FC-1271a) is an orally active and non-estrogenic selective estrogen receptor modulator (SERM) with Ki values of 380 and 410 nM for estrogen receptor α (ERα) and ERβ, respectively. Ospemifene inhibits caspase-3 activity. Ospemifene inhibits neuronal degeneration, prevents bone loss, and increases vaginal weight and vaginal epithelial height. Ospemifene has anticancer activity against breast cancer[1][2][3][4][5][6].

• Product Name Alternative:

  FC-1271a

• UNSPSC:

  12352005

• Hazard Statement:

  H410

• Target:

  Caspase; Estrogen Receptor/ERR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Endocrinology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Ospemifene.html

• Purity:

  99.84

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  ClCC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCO)C=C2)\C3=CC=CC=C3

• Molecular Formula:

  C24H23ClO2

• Molecular Weight:

  378.89

• Precautions:

  H410

• References & Citations:

  [1]Qiang Qv.et al.Selective estrogenic effects of a novel triphenylethylene compound, FC1271a, on bone, cholesterol level, and reproductive tissues in intact and ovariectomized rats. Endocrinology.Feb;141 (2) :809-20. 25. (2000) .|[2]Tracy L. Taras et al.In vitro and in vivo biologic effects of Ospemifene (FC-1271a) in breast cancer. The Journal of Steroid Biochemistry and Molecular Biology 77 (4-5) :271-9, (2001) .|[3]Unkila M, et, al. Vaginal effects of ospemifene in the ovariectomized rat preclinical model of menopause. J Steroid Biochem Mol Biol. 2013 Nov;138:107-15.|[4]Bruyniks N, et, al. Systematic indirect comparison of ospemifene versus local estrogens for vulvar and vaginal atrophy. Climacteric. 2017 Jun; 20 (3) : 195-204.|[5]Pietrzak B A, et al. Posttreatment with ospemifene attenuates hypoxia-and ischemia-induced apoptosis in primary neuronal cells via selective modulation of estrogen receptors. Neurotoxicity Research, 2023, 41 (4) : 362-379.|[6]Burich RA, et al. Ospemifene and 4-hydroxyospemifene effectively prevent and treat breast cancer in the MTag.Tg transgenic mouse model. Menopause. 2012 Jan;19 (1) :96-103.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  Caspase 3

• CAS Number:

  [128607-22-7]