Products for Research Use Only
RegisterLogin

Tubulysin A

CAT: 0804-HY-15995-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-15995-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Tubulysin A (TubA) is an anticancer and antiangiogenic agent with anti-microtubule, anti-mitosis and anti-proliferative activity against a variety of cancer cells with IC50 values in the pmol range. It can induce apoptosis of cancer cells and has no effect on normal cells. Tubulysins are a group of potent cytotoxins consisting of nine members (A-I) . Tubulysin A can synthesize ADC as ADC Cytotoxin[1][2][3][4].
CAS Number
205304-86-5
Product Name Alternative
TubA
UNSPSC
12352203
Hazard Statement
H301, H311, H315, H319, H331, H335
Target
ADC Payload; Antibiotic; Microtubule/Tubulin; Mitosis
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Tubulysin-A.html
Purity
99.32
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@]([C@@H](C)CC)([H])NC([C@@H](CCCC1)N1C)=O)N(COC(CC(C)C)=O)[C@@H](C(C)C)C[C@H](C2=NC(C(N[C@H](C[C@H](C)C(O)=O)CC3=CC=C(O)C=C3)=O)=CS2)OC(C)=O
Molecular Formula
C43H65N5O10S
Molecular Weight
844.07
Precautions
H301, H311, H315, H319, H331, H335
References & Citations
[1]Kaur G, et al. Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product. Biochem J. 2006 Jun 1;396 (2) :235-42.|[2]Sasse F, et al. Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties. J Antibiot (Tokyo) . 2000 Sep;53 (9) :879-85.|[3]Khalil MW, et al. Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria. Chembiochem. 2006 Apr;7 (4) :678-83.|[4]Schluep T, et al. Polymeric tubulysin-peptide nanoparticles with potent antitumor activity. Clin Cancer Res. 2009 Jan 1;15 (1) :181-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Traditional Cytotoxic Agents

Related Products

CatalogName
HY-179159Tubulin-IN-60
HY-179160Tubulin-IN-61
HY-178960Tubulin-IN-59
HY-178325Tubulin-IN-57
HY-177138Tubulin-IN-52
HY-175874Tubulin-IN-55
HY-175512Tubulin-IN-53
HY-178357Tubulin-IN-58
HY-175555Tubulin-IN-54
HY-177021Tubulin-IN-51

Alternative Products

CatalogName
T13945Tubulysin
468362-01Tubulysin A
MBS130368-01Tubulysin-A
T13941-01Tubulysin G
A18475-10Tubulysin 10mg
A18475-1Tubulysin 1mg
GTR19226832-01Tubulysin H
GTR19226898-01Tubulysin D
T13944-01Tubulysin M
T13938-01Tubulysin C

Popular Products