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Subtilisin

CAT: 0804-HY-P2729-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2729-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Subtilisin (EC 3.4.21.14) is a bacterial serine protease. Subtilisin induces Apoptosis. Subtilisin stimulates the expression of pro-allergic cytokines (IL-1α, IL-33) . Subtilisin induces prototypic allergic lung inflammation. Subtilisin exhibits anticancer activity against breast and colon cancer. Subtilisin shows antifouling activity. Subtilisin can be used as a detergent additive[1][2][3][4][5][6].
CAS Number
9014-01-1
Product Name Alternative
EC 3.4.21.14
UNSPSC
12352204
Hazard Statement
H302, H315, H318, H335, H400, H411
Target
Apoptosis; Bacterial; Interleukin Related; Ser/Thr Protease
Type
Enzyme
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/subtilisin.html
Solubility
H2O : ≥ 100 mg/mL
Smiles
[Subtilisin]
Precautions
H302, H315, H318, H335, H400, H411
References & Citations
[1]Philipp M, et al. Kinetics of subtilisin and thiolsubtilisin. Mol Cell Biochem. 1983;51 (1) :5-32.|[2]Azrin NAM, et al. Versatility of subtilisin: A review on structure, characteristics, and applications. Biotechnol Appl Biochem. 2022 Dec;69 (6) :2599-2616.|[3]Singh N, et al. Subtilisin from Bacillus amyloliquefaciens induces apoptosis in breast cancer cells through ubiquitin-proteasome-mediated tubulin degradation. Int J Biol Macromol. 2022 Nov 1;220:852-865.|[4]Leroy C, et al. Influence of subtilisin on the adhesion of a marine bacterium which produces mainly proteins as extracellular polymers. J Appl Microbiol. 2008 Sep;105 (3) :791-9.|[5]Alexander PA, et al. Stabilizing mutations and calcium-dependent stability of subtilisin. Biochemistry. 2001 Sep 4;40 (35) :10640-4.|[6]Florsheim E, et al. Integrated innate mechanisms involved in airway allergic inflammation to the serine protease subtilisin. J Immunol. 2015 May 15;194 (10) :4621-30.
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20°C for 2 years
Scientific Category
Enzyme
Clinical Information
No Development Reported

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