R406

CAT: 0804-HY-12067-01Size: 5 mgDry Ice: NoHazardous: No

CAT#:0804-HY-12067-01Size:5 mg

Selected

PRICE

AVAILABILITY: InStock

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

1 / 1

Description

R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 reduces immune complex-mediated inflammation[1]. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM) [2].

CAS Number

[841290-81-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; FLT3; Syk

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/R406.html

Purity

97.91

Solubility

DMSO : ≥ 61 mg/mL

Smiles

COC1=CC(NC2=NC(NC3=NC(N4)=C(C=C3)OC(C)(C)C4=O)=C(C=N2)F)=CC(OC)=C1OC.OS(C5=CC=CC=C5)(=O)=O

Molecular Formula

C28H29FN6O8S

Molecular Weight

628.63

Precautions

H302, H315, H319, H335

References & Citations

[1]Sylvia Braselmann, et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther. 2006 Dec;319 (3) :998-1008.|[2]Hoon-Suk Cha , et al. A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J Pharmacol Exp Ther. 2006 May;317 (2) :571-8.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Related Products

Catalog	Name

Alternative Products

Catalog	Name
MBS3606125-01	R406
MBS386028-01	R406 (Tamatinib)
A10769-2	R406 2mg
A10769-5	R406 5mg
MBS386029-01	R406 besylate

R406

Related Products

Alternative Products

Popular Products