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Sennidin A

CAT: 0804-HY-N6936-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6936-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sennidin A, isolated from the leaves of Cassia angustifolia, inhibits HCV NS3 helicase, with an IC50 of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation[1][2].
CAS Number
641-12-3
UNSPSC
12352005
Hazard Statement
H302
Target
Akt; GLUT; HCV
Type
Natural Products
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; PI3K/Akt/mTOR
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sennidin-a.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(O)C=C(C(O)=O)C=C2[C@@]([C@@]3([H])C4=CC(C(O)=O)=CC(O)=C4C(C5=C(O)C=CC=C35)=O)([H])C6=CC=CC(O)=C16
Molecular Formula
C30H18O10
Molecular Weight
538.46
Precautions
P264-P270-P330-P501
References & Citations
[1]Furuta A, et al. Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase. Int J Mol Sci. 2015 Aug 7;16 (8) :18439-53.|[2]Daigo Abe, et al. Sennidin stimulates glucose incorporation in rat adipocytes. Life Sciences. 2006.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
GLUT4

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