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IONIS-MAPTRx

CAT: 0804-HY-132582-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-132582-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IONIS-MAPTRx (BIIB080) is the first Tau-lowering antisense oligonucleotide (ASO) . IONIS-MAPTRx has the potential for the research of Alzheimer Disease[1].
CAS Number
2857842-32-9
Product Name Alternative
BIIB080; ISIS 814907
UNSPSC
12352208
Target
Tau Protein
Type
Oligonucleotides
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ionis-maptrx.html
Purity
92.31
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
[IONIS-MAPTRx]
Molecular Weight
6430.39
References & Citations
[1]Laurence Mignon, et al. Design of the First-in-Human Study of IONIS-MAPTRx, a Tau-lowering Antisense Oligonucleotide, in Patients With Alzheimer Disease (S2.006) . Neurology Apr 2018, 90 (15 Supplement) S2.006.|[2]Rationale for and Development of IONIS-MAPTRx, the First Tau-lowering Antisense Oligonucleotide, in Patients with Mild AD|[3]DeVos SL, Miller RL, Schoch KM, et al. Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy. Sci Transl Med. 2017;9 (374) :eaag0481. |[4]Methods for reducing tau expression. WO2023004390A1
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 2

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