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MY10

CAT: 0804-HY-123856-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123856-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MY10 is a potent and orally active receptor protein tyrosine phosphatase (RPTPβ/ζ) inhibitor. MY10 reduces NF-κB p65 expression. MY10 activates tyrosine phosphorylation of c-Met. MY10 prevents the alcohol-induced downregulation of Ptprz1 and Alk expression. MY10 attenuates binge-like ethanol consumption and ethanol reward. MY10 can be used in the study of neurological and vascular diseases[1][2][3][4][5].
CAS Number
2204270-73-3
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; c-Met/HGFR; NF-κB; Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/my10.html
Purity
99.76
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC(SC1=CC=C(C=C1)COC2=CC=C(SC(F)(F)F)C=C2)(F)F
Molecular Formula
C15H10F6OS2
Molecular Weight
384.36
References & Citations
[1]Fernández-Calle R, et, al. Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol. Neuropharmacology. 2018 Jul 15;137:86-95. |[2]Del Campo M, et al. Role of Receptor Protein Tyrosine Phosphatase β/ζ in Neuron-Microglia Communication in a Cellular Model of Parkinson's Disease. Int J Mol Sci. 2021 Jun 22;22 (13) :6646.|[3]Fernández-Calle R, et al. Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication. Sci Rep. 2020 Nov 20;10 (1) :20259.|[4]Kastana P, et al. Genetic deletion or tyrosine phosphatase inhibition of PTPRZ1 activates c-Met to up-regulate angiogenesis and lung adenocarcinoma growth. Int J Cancer. 2023 Sep 1;153 (5) :1051-1066.|[5]Calleja-Conde J, et al. Inhibition of Receptor Protein Tyrosine Phosphatase β/ζ Reduces Alcohol Intake in Rats. Alcohol Clin Exp Res. 2020 May;44 (5) :1037-1045.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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