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Prinaberel

CAT: 0804-HY-14933-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14933-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Prinaberel (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC50s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. Prinaberel displays >200-fold selectivity for ERβ over ERα. Prinaberel is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. Prinaberel induces ovarian cancer apoptosis[1][2][3].
CAS Number
524684-52-4
Product Name Alternative
ERB-041
UNSPSC
12352005
Hazard Statement
H302, H319
Target
Apoptosis; Estrogen Receptor/ERR; Wnt
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Prinaberel.html
Purity
98.05
Solubility
DMSO : ≥ 40 mg/mL
Smiles
OC1=CC(C=C)=C(OC(C2=CC=C(O)C(F)=C2)=N3)C3=C1
Molecular Formula
C15H10FNO3
Molecular Weight
271.24
Precautions
H302, H319
References & Citations
[1]Malamas MS, et al. Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004;47 (21) :5021-5040.|[2]Chaudhary SC, et al. Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer Prev Res (Phila) . 2014;7 (2) :186-198.|[3]Chan KKL, et al. Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer. Cancer Cell Int. 2018;18:65. Published 2018 May 1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
ERα; ERβ

Alternative Products

CatalogName
TQ0149-01Prinaberel
A21255-100Prinaberel 100mg
A21255-1Prinaberel 1mg
A21255-25Prinaberel 25mg
A21255-50Prinaberel 50mg
A21255-10Prinaberel 10mg
A21255-5Prinaberel 5mg
A21255-10mM-DPrinaberel 10mM * 1mL in DMSO

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