Ligustilide

• Description :

  Ligustilide is is a bioactive phthalide derivative isolated from Angelica sinensis and Chuanxiong. Ligustilide exhibits neuroprotective, anti-cancer, anti-inflammatory, and vasodilator effects[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H301

• Target :

  Apoptosis; Autophagy

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Autophagy

• Field of Research :

  Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/Ligustilide.html

• Purity :

  99.17

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1O/C(C2=C1C=CCC2)=C\CCC

• Molecular Formula :

  C12H14O2

• Molecular Weight :

  190.24

• Precautions :

  H301

• References & Citations :

  [1]Wu Q, et al. Protective effect of ligustilide against glutamate-induced apoptosis in PC12 cells. Yao Xue Xue Bao. 2015 Feb;50 (2) :162-8.|[2]Jing Ma, et al. Ligustilide promotes apoptosis of cancer-associated fibroblasts via the TLR4 pathways. Food Chem Toxicol. 2020 Jan;135:110991.|[3]Eun Sik Choi, et al. Ligustilide attenuates vascular inflammation and activates Nrf2/HO-1 induction and, NO synthesis in HUVECs. Phytomedicine. 2018 Jan 1;38:12-23.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• CAS Number :

  [4431-01-0]