Ligustilide

• Description:

  Ligustilide is is a bioactive phthalide derivative isolated from Angelica sinensis and Chuanxiong. Ligustilide exhibits neuroprotective, anti-cancer, anti-inflammatory, and vasodilator effects[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  Apoptosis; Autophagy

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Autophagy

• Field of Research:

  Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Ligustilide.html

• Purity:

  99.17

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1O/C(C2=C1C=CCC2)=C\CCC

• Molecular Formula:

  C12H14O2

• Molecular Weight:

  190.24

• Precautions:

  H301

• References & Citations:

  [1]Wu Q, et al. Protective effect of ligustilide against glutamate-induced apoptosis in PC12 cells. Yao Xue Xue Bao. 2015 Feb;50 (2) :162-8.|[2]Jing Ma, et al. Ligustilide promotes apoptosis of cancer-associated fibroblasts via the TLR4 pathways. Food Chem Toxicol. 2020 Jan;135:110991.|[3]Eun Sik Choi, et al. Ligustilide attenuates vascular inflammation and activates Nrf2/HO-1 induction and, NO synthesis in HUVECs. Phytomedicine. 2018 Jan 1;38:12-23.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• CAS Number:

  [4431-01-0]