LHQ490

CAT: 0804-HY-163620Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-163620Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

LHQ490 is a selective FGFR2 inhibitor, with an IC50 of 5.2 nM. LHQ490 efficiently inhibits the proliferation of BaF3-FGFR2 cells with an IC50 value of 1.4 nM. LHQ490 inhibits FGFR2-driven cancer cell proliferation and induces apoptosis of FGFR2-driven cancer cells[1].

UNSPSC

12352005

Target

Apoptosis; FGFR

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lhq490.html

Smiles

C=CC(NC1=CC=C(C=C1)C2=C(C3=C(N=CN=C3N2C)N)C4=CC=C(C(F)=C4)C5(COC5)N(C(C)C)CC)=O

Molecular Formula

C30H33FN6O2

Molecular Weight

528.62

References & Citations

[1]Li H, et al. Discovery of LHQ490 as a highly selective fibroblast growth factor receptor 2 (FGFR2) inhibitor. Eur J Med Chem. 2024 Jun 5;272:116473.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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