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YX862

CAT: 0804-HY-163845Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163845Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YX862 is a selective HDAC8 PROTAC degrader and induces the degradation of HDAC8 with maximum degradation > 95% at 250 nM in MDA-MB-231 cells (Sturcture Note: (Blue: VHL E3 ligand , Black: linker; Pink: HDAC8 inhibitor (HY-163846) ).
CAS Number
3092219-09-2
UNSPSC
12352005
Target
HDAC; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yx862.html
Smiles
O=C([C@@H](NC(CCCCCCCN1CCN(C2=CC=C(C=C2)C(NNCCCCCC)=O)CC1)=O)C(C)(C)C)N3[C@@H](C[C@H](C3)O)C(N[C@H](C4=CC=C(C=C4)C5=C(N=CS5)C)C)=O
Molecular Formula
C48H72N8O5S
Molecular Weight
873.20
References & Citations
[1]Xiao Y, et al. Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8. J Med Chem. 2024 Jul 1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T89206-01YX862

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