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Ketorolac

CAT: 0804-HY-B0580-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0580-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ketorolac (RS37619) is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac tromethamine is also a DDX3 inhibitor that can be used for cancer research[1][4].
CAS Number
74103-06-3
Product Name Alternative
RS37619
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; COX
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/ketorolac.html
Purity
99.93
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1C2=CC=C(C(C3=CC=CC=C3)=O)N2CC1)O
Molecular Formula
C15H13NO3
Molecular Weight
255.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Waterbury LD, et al. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006 Jun;22 (6) :1133-40.|[2]Fracon RN, et al. Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats. J Appl Oral Sci. 2010 Dec;18 (6) :630-4.|[3]Hsieh YC, et al. Intrathecal ketorolac pretreatment reduced spinal cord ischemic injury in rats. Anesth Analg. 2005 Apr;100 (4) :1134-9.|[4]Samal SK, et al. Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer. Sci Rep. 2015 Apr 28;5:9982.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX-1; COX-2
Citation 01
BMC Anesthesiol. 2025 Apr 10;25 (1) :165.|Eur J Med Chem. 2024 Dec 5:279:116842.|Immunobiology. 2025 Mar;230 (2) :152867.

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