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Recombinant Human Epoxide hydrolase 2 (EPHX2)

CAT: 0399-CSB-EP007735HU-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0399-CSB-EP007735HU-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Product Name Alternative
Epoxide hydratase; Soluble epoxide hydrolase ; SEHLipid-phosphate phosphatase (EC:3.1.3.76)
Abbreviation
Recombinant Human EPHX2 protein
Gene Name
EPHX2
UniProt
P34913
Expression Region
1-555aa
Organism
Homo sapiens (Human)
Target Sequence
MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM
Tag
N-terminal 6xHis-SUMO-tagged
Type
Developed Protein
Source
E.coli
Field of Research
Cancer
Relevance
Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.
Endotoxin
Not test
Purity
Greater than 90% as determined by SDS-PAGE.
Activity
Not Test
Form
Liquid or Lyophilized powder
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Function
Bifunctional enzyme
Molecular Weight
78.6 kDa
References & Citations
CDNA cloning and expression of a soluble epoxide hydrolase from human liver.Beetham J.K., Tian T., Hammock B.D.Arch. Biochem. Biophys. 305:197-201 (1993)
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Protein Length
Full Length

UniProtKB · P34913

Bifunctional epoxide hydrolase 2

HYES_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P34913
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EPHX2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2Z3B1, B3KTU8, B3KUA0, G3V134, J3KPH7, Q16764, Q9HBJ1, Q9HBJ2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationLipoproteinPhosphoprotein

Coding sequence diversity

Alternative splicing

Biological process

Aromatic hydrocarbons catabolismDetoxificationLipid metabolism

Cellular component

CytoplasmPeroxisome

Molecular function

HydrolaseMultifunctional enzyme

Ligand

MagnesiumMetal-binding

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CatalogName
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GTR18223525EPHX2/Epoxide Hydrolase 2 Antibody
222475-01EPHX2 (CEH, Cytosolic epoxide Hydrolase, EPHX2, Epoxide Hydratase, Epoxide Hydrolase 2, Epoxide Hydrolase 2 Cytoplasmic, epoxide Hydrolase 2, cytosolic, Epoxide Hydrolase Soluble, HYES_HUMAN, SEH, Soluble epoxide Hydrolase, ) discontinued
126396EPHX2 (Bifunctional Epoxide Hydrolase 2)
RQ8730Epoxide hydrolase 2 Antibody / EPHX2
GTR19027812-01Recombinant Human Epoxide hydrolase 2 (EPHX2)
AP70274-01Recombinant Human Epoxide hydrolase 2(EPHX2)
136075Epoxide Hydrolase 2, Soluble (EPHX2, epoxide hydrolase 2, cytosolic, soluble epoxide hydrolase) discontinued
MBS952222-01Recombinant Rat Epoxide hydrolase 2 (Ephx2)

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