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A71623

CAT: 0804-HY-P1096-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1096-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A71623, a CCK-4-based peptide, is a potent and highly selective CCK-A full agonist. The IC50s for A-71623 are 3.7 nM in guinea pig pancreas (CCK-A) and 4500 nM in cerebral cortex (CCK-B) in radioligand binding assays, respectively[1].
CAS Number
130408-77-4
UNSPSC
12352209
Target
Cholecystokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/a71623.html
Purity
99.34
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CCCCNC(NC(C=CC=C1)=C1C)=O)C(N[C@@H](CC(O)=O)C(N(C)[C@H](C(N)=O)CC2=CC=CC=C2)=O)=O)[C@@H](NC(OC(C)(C)C)=O)CC3=CNC4=CC=CC=C34
Molecular Formula
C44H56N8O9
Molecular Weight
840.96
References & Citations
[1]C W Lin, et al. Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol Pharmacol. 1991 Mar;39 (3) :346-51.|[2]K E Asin, et al. Effects of selective CCK receptor agonists on food intake after central or peripheral administration in rats. Brain Res. 1992 Jan 31;571 (1) :169-74.|[3]Emily A.L. Wozniak, et al. Cholecystokinin 1 Receptor (Cck1R) Activates mTORC1 signaling and is Protective to Purkinje cells in SCA Mice. bioRxiv. February 17, 2021.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCKAR

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