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LY3130481

CAT: 0804-HY-108707-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108707-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY3130481 is an orally available AMPA receptor antagonist, selectively inhibiting the IC50 value of AMPA/TARP γ-8 at 65 nM. LY3130481 has anticonvulsant, antiepileptic, and pain-relieving effects[1][2].
CAS Number
1610802-47-5
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly3130481.html
Concentration
10mM
Purity
99.73
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N1)SC2=C1C=CC([C@H](C)C3=NN(C4=CC=C(OCCO)C=N4)C=C3)=C2
Molecular Formula
C19H18N4O3S
Molecular Weight
382.44
References & Citations
[1]Gardinier KM, et al. Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8. J Med Chem. 2016 May 26;59 (10) :4753-68.|[2]Kelly L Knopp, et al. Modulation of TARP γ 8-Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain. J Pharmacol Exp Ther. 2019 Jun;369 (3) :345-363.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor

Alternative Products

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BA6734-5.1LY3130481
A19714-100LY3130481 100mg
A19714-5LY3130481 5mg
A19714-50LY3130481 50mg
A19714-25LY3130481 25mg
A19714-10LY3130481 10mg
A19714-1LY3130481 1mg
A19714-10mM-DLY3130481 10mM * 1mL in DMSO

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