FiVe1

CAT: 0804-HY-124757-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-124757-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

FiVe1 is a vimentin (VIM) inhibitor. FiVe1 binds to the rod domain of VIM, causing metaphase VIM disassembly and hyperphosphorylation at Ser56, ultimately leading to mitotic catastrophe, multinucleation, and loss of stemness. FiVe1 has anticancer activity against soft tissue sarcomas. FiVe1 increases the sensitivity of ovarian cancer to Cisplatin. FiVe1 can be used for researches of mesenchymal cancers (including breast cancer and soft tissue sarcoma) and ovarian cancers[1][2][3].

CAS Number

932359-76-7

UNSPSC

12352005

Target

Mitosis; Proteasome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/five1.html

Purity

99.87

Solubility

DMSO : 3.6 mg/mL (ultrasonic; warming)

Smiles

ClC1=CC(N2CCN(C3=C4C=CC=C(Cl)C4=NN=C3)CC2)=CC=C1

Molecular Formula

C18H16Cl2N4

Molecular Weight

359.25

References & Citations

[1]Michael J Bollong, et al. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proc Natl Acad Sci U S A. 2017 Nov 14;114 (46) :E9903-E9912.|[2]Martínez-Peña F, et al. Synthesis and biological evaluation of novel FiVe1 derivatives as potent and selective agents for the treatment of mesenchymal cancers. Eur J Med Chem. 2022 Nov 15;242:114638.|[3]Möltgen S, et al. Cisplatin Protein Binding Partners and Their Relevance for Platinum Drug Sensitivity. Cells. 2020 May 26;9 (6) :1322.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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