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Bizine

CAT: 0804-HY-121095-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121095-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bizine, a Phenelzine analogue, is a potent and selective LSD1 inhibitor, with a b>Ki of 59 nM. Bizine can modulate bulk histone methylation in cancer cells. Bizine shows neuroprotective effects[1].
CAS Number
1591932-50-1
UNSPSC
12352005
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bizine.html
Purity
96.2
Solubility
10 mM in DMSO
Smiles
NNCCC1=CC=C(NC(CCCC2=CC=CC=C2)=O)C=C1
Molecular Formula
C18H23N3O
Molecular Weight
297.39
References & Citations
[1]Prusevich P, et, al. A selective phenelzine analogue inhibitor of histone demethylase LSD1. ACS Chem Biol. 2014 Jun 20;9 (6) :1284-93.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1

Chemical Information

Bizine Dihydrochloride
CAS Number1591932-50-1
PubChem CID77014305
IUPAC NameN-[4-(2-hydrazinylethyl)phenyl]-4-phenylbutanamide;dihydrochloride
Molecular FormulaC18H25Cl2N3O
Molecular Weight370.3
Topological Polar Surface Area67.2
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count3
Rotatable Bond Count8
Heavy Atom Count24
Formal Charge0
Complexity307
SMILES
C1=CC=C(C=C1)CCCC(=O)NC2=CC=C(C=C2)CCNN.Cl.Cl
InChI
InChI=1S/C18H23N3O.2ClH/c19-20-14-13-16-9-11-17(12-10-16)21-18(22)8-4-7-15-5-2-1-3-6-15;;/h1-3,5-6,9-12,20H,4,7-8,13-14,19H2,(H,21,22);2*1H
InChIKey
MUAMIWJQSFQIGT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Bizine Dihydrochloride
CAS: 1591932-50-1
CID: 77014305
Formula: C18H25Cl2N3O
MW: 370.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight370.3
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count3
Rotatable Bond Count8
Exact Mass369.1374678
Monoisotopic Mass369.1374678
Topological Polar Surface Area67.2 Ų
Heavy Atom Count24
Formal Charge0
Complexity307
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3602274-01Bizine
T70163-01Bizine dihydrochloride

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