Recombinant Mouse DPPIV/CD26 Protein(His Tag)
CAT:
763-PDMM100149-02
Size:
20 µg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No




Recombinant Mouse DPPIV/CD26 Protein(His Tag)
- Background: Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the N-terminus of polypeptides , such as chemokines , neuropeptides , and peptide hormones. The enzyme is a type II transmembrane glycoprotein , expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV). The soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. As both a regulatory enzyme and a signalling factor , DPP4 has been evaluated and described in many studies. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). This causes an increase in glucose-dependent stimulation , resulting in a lowering of blood glucose levels. Recent studies have shown that DPP4 inhibitors can induce a significant reduction in glycosylated haemoglobin (HbA(1c)) levels , either as monotherapy or as a combination with other antidiabetic agents. Research has also demonstrated that DPP4 inhibitors portray a very low risk of hypoglycaemia development , and are a new pharmacological class of drugs for treating Type 2 diabetes.
- Abbreviation: DPPIV/CD26
- Synonyms: DPP, Adenosine Deaminase Complexing Protein, ADCP, ADABP, ADCP2, Adenosine Deaminase Complexing Protein 2, DPPIV, TP103, Cd26, Dpp4, Dipeptidyl peptidase IV (DPP IV), THAM
- CAS Number: 9000-83-3
- UniProt: P28843
- Accession Number: P28843
- Host: Mammalian
- Origin Species: Mouse
- Tag: C-His
- Sequence: Ser37-His760
- Purity: > 90% as determined by reducing SDS-PAGE.
- Bioactivity: Not validated for activity
- Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
- Molecular Weight: 90 kDa
- Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
- Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.