N-Desmethylclozapine-d8 (hydrochloride)

N-Desmethylclozapine-d8 (hydrochloride)

• CAS Number: 2705402-91-9
• UNSPSC Description: N-Desmethylclozapine-d8 (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].
• Target Antigen: Drug Metabolite; mAChR; Opioid Receptor; Virus Protease
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Purity: 99.74
• Solubility: 10 mM in DMSO
• Smiles: ClC1=CC=C2NC3=CC=CC=C3C(N4C([2H])([2H])C([2H])([2H])NC([2H])([2H])C4([2H])[2H])=NC2=C1.[H]Cl
• Molecular Weight: 357.31
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Li Z, et al. N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarinic receptors. Neuropsychopharmacology. 2005 Nov;30(11):1986-95.|[3]Odagaki Y, et al. Comparative analysis of pharmacological properties of xanomeline and N-desmethylclozapine in rat brain membranes. J Psychopharmacol. 2016 Sep;30(9):896-912.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported