Tylosin

• Description:

  Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Antibiotic; Bacterial

• Type:

  Natural Products

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/Tylosin.html

• Purity:

  99.81

• Solubility:

  DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL

• Smiles:

  C[C@@H] (O[C@@]1 ([H]) O[C@H] ([C@H] ([C@@H] (CC2=O) O) C) [C@H] (C[C@H] (C (/C=C/C (C) =C/[C@H] (CO[C@H] (O[C@H] (C) [C@@H] (O) [C@H]3OC) [C@@H]3OC) [C@@H] (CC) O2) =O) C) CC=O) [C@H] ([C@@H] ([C@H]1O) N (C) C) O[C@@] (O[C@@H] (C) [C@@H]4O) ([H]) C[C@]4 (O) C

• Molecular Formula:

  C46H77NO17

• Molecular Weight:

  916.10

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Mingfu Liu, et al. Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy. Proc Natl Acad Sci U S A. 2002 Nov 12; 99 (23) : 14658-14663.|[2]Carlo Pinna, et al. In Vitro Evaluation of the Effects of Tylosin on the Composition and Metabolism of Canine Fecal Microbiota. Animals (Basel) . 2020 Jan; 10 (1) : 98.|[3]Niels Møller Andersen, et al. Inhibition of Protein Synthesis on the Ribosome by Tildipirosin Compared with Other Veterinary Macrolides. Antimicrob Agents Chemother. 2012 Nov; 56 (11) : 6033-6036.|[4]Ayse Er, et al. Effects of tylosin on serum cytokine levels in healthy and lipopolysaccharide-treated mice. Acta Vet Hung. 2010 Mar;58 (1) :75-81.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  Macrolide

• CAS Number:

  1401-69-0