WNK3 protein Antibody, ALEXA FLUOR 647

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• Catalog number
  bs-1945R-A647
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• Size
  100ul

# #

• Long name
  WNK3 protein Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
• Also known as
  Anti-WNK3 protein PAb ALEXA FLUOR 647
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 647
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  WNK3 protein
• Specificity
  This is a highly specific antibody against WNK3 protein.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  475-520/1800
• Subcellular location
  Cytoplasm
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human WNK3 protein
• Gene ID Number
  65267
• Swiss Prot
  Q9BYP7
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway. Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner. Isoform 1, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the activity of SLC12A3.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  650nm/665nm
• Synonyms
  PRKWNK3; Serine/threonine-protein kinase WNK3; Protein kinase lysine-deficient 3; Protein kinase with no lysine 3; WNK3; KIAA1566
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-WNK3 protein exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 647
• French translation
  anticorps

#

• Gene target
  WNK3   protein  
• Gene symbol
  WNK3
• Short name
  Anti-WNK3 protein
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 647
• Alternative name
  WNK3 protein Polyclonal Antibody, ALEXA FLUOR 647
• Alternative technique
  antibodies
• Alternative to gene target
  WNK lysine deficient protein kinase 3, WNK3 and IDBG-71035 and ENSG00000196632 and 65267, transferase activity, Cell surfaces, Wnk3 and IDBG-178902 and ENSMUSG00000041245 and 279561, WNK3 and IDBG-637533 and ENSBTAG00000023182 and

Gene info

• Identity
  HGNC:14543
• Gene
  WNK3
• Long gene name
  WNK lysine deficient protein kinase 3
• Synonyms gene
  • PRKWNK3
• Synonyms gene name
  • protein kinase, lysine deficient 3
• GenBank acession
  • AJ409088
• Locus
  Xp11.22
• Discovery year
  2001-02-07
• Entrez gene record
  65267
• RefSeq identity
  • NM_020922
• Classification
  • WNK lysine deficient protein kinases
• VEGA ID
  OTTHUMG00000021626
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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