Vatalanib, Free Base
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Catalog number2026-5
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Price130.08 USD
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Size5 mg
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Alternative_nameCGP-79787; PTK 787; ZK222584
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DescriptionCell-permeable. An inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC₅₀ = 77 nM) and VEGFR-2 (FLK-1/KDR, IC₅₀ = 37 nM), with slightly higher potency against the latter. At higher concentrations, other tyrosine kinases are also inhibited, including PDGFR-β (IC₅₀ = 580 nM), c-KIT (IC₅₀ = 730 nM), FLT-4 (IC₅₀ = 660 nM) and c-FMS (IC₅₀ = 1.4 µM). On the other hand, vatalanib is not active against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC₅₀ > 10 µM).
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CAS Number212141-54-3
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₀H₁₅ClN₄
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Molecular Weight346.81
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (25 mg/ml) or EtOH (~ 6 mg/ml)
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HandlingProtect from air and moisture
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Tag LineA potent inhibitor of the VEGFR tyrosine kinases
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24 months
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MDL NumberMFCD08458963
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PubChem CID151194
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SMILESC1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4
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InChiInChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24- 25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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InChi KeyYCOYDOIWSSHVCK-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameVatalanib, Free Base
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Alternative nameVatalanib, Free Base
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