UBE2D3 Antibody

• Catalog number
  bs-8355R
• Price
  Please ask
• Size
  0.1ml

• Long name
  UBE2D3 Primary Polyclonal Antibody
• Also known as
  UBE2D3 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  UBE2D3
• Specificity
  This is a highly specific antibody against UBE2D3.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human UBE2D3
• Gene ID number
  7323
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  E217KB3; MGC43926; MGC5416; UB2D3_HUMAN; UBC 4/5; UBC4/5; UBC4/5 homolog yeast; UBCH 5C; UBCH5C; Ube2d3; Ubiquitin carrier protein; Ubiquitin carrier protein D3; Ubiquitin conjugating enzyme E2 17 kDa 3; Ubiquitin conjugating enzyme E2 D3; Ubiquitin conjugating enzyme E2D 3 homologous to yeast UBC4/5; Ubiquitin conjugating enzyme E2D 3 UBC4/5 homolog yeast; Ubiquitin conjugating enzyme E2D 3; Ubiquitin protein ligase D3; Ubiquitin-conjugating enzyme E2 D3; Ubiquitin-conjugating enzyme E217KB 3; Ubiquitin-conjugating enzyme E2-17 kDa 3; Ubiquitin-protein ligase D3.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  UBE2D3  
• Gene symbol
  UBE2D3-AS1, UBE2D3
• Short name
  Anti-UBE2D3
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  UBE2D3 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  ubiquitin-conjugating enzyme E2D 3, E2(17)KB3 and UBC4/5 and UBCH5C, UBE2D3 and IDBG-32113 and ENSG00000109332 and 7323, acid-amino acid ligase activity, nuclei, Ube2d3 and IDBG-269073 and ENSMUSG00000078578 and 66105, IDBG-639940 and IDBG-639940 and ENSBTAG00000045753 and

Gene info

• Identity
  HGNC:54095
• Gene
  UBE2D3-AS1
• Long gene name
  UBE2D3 antisense RNA 1
• Locus
  4q24
• Discovery year
  2018-11-04
• Entrez gene record
  105377348
• RefSeq identity
  • NR_131185
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:12476
• Gene
  UBE2D3
• Long gene name
  ubiquitin conjugating enzyme E2 D3
• Synonyms gene name
  • ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5)
  • ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
  • ubiquitin-conjugating enzyme E2D 3
• Synonyms
  • UbcH5C
• GenBank acession
  • U39318
• Locus
  4q24
• Discovery year
  1997-03-21
• Entrez gene record
  7323
• Pubmed identfication
  • 8530467
• RefSeq identity
  • NM_181893
• Classification
  • Ubiquitin conjugating enzymes E2
• VEGA ID
  OTTHUMG00000131119

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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