TGR5-Receptor-Agonist
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Catalog numberB1635-5
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PricePlease ask
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Size5 mg
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Alternative_nameTGR5-Receptor-Agonist; TGR5; 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-4-isoxazolecarboxamide; MDK00245; MDK-00245; MDK 00245
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DescriptionTGR5 Receptor Agonist, a potent TGR5(GPCR19) agonist, showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5).
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CAS Number1197300-24-5
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₈H₁₄Cl₂N₂O₂
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Molecular Weight361.22
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Cell PermeableYes
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Purity>98%
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SolubilitiesDMSO
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HandlingProtect from air and light
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Tag LineA potent TGR5 G-protein receptor (GPCR19) agonist
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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MDL NumberNA
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PubChem CID44605616
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SMILESCC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)N(C)C3=CC=C(C=C3)Cl
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InChi1S/C18H14Cl2N2O2/c1-11-16(17(21-24-11)14-5-3-4-6-15(14)20)18(23)22(2)13-9-7-12(19)8-10-13/h3-10H,1-2H3
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InChi KeyIGRCWJPBLWGNPX-UHFFFAOYSA-N
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MSDS AvailableYes
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Additional descriptionThe receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Gene target
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Gene symbolGPBAR1
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Short nameTGR5-Receptor-Agonist
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Alternative nameTGR5-Receptor-Agonist
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Gene info
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Identity
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Gene
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Long gene nameG protein-coupled bile acid receptor 1
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-01-24
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- G protein-coupled bile acid receptor
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VEGA ID