TAK1(Thr187) Antibody

• Catalog number
  bs-3438R
• Price
  Please ask
• Size
  0.1ml

• Long name
  TAK1(Thr187) Primary Polyclonal Antibody
• Also known as
  TAK1(Thr187) PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  TAK1 Thr187
• Specificity
  This is a highly specific antibody against TAK1 Thr187.
• Modification s
  Phosphorylation
• Modification site s
  Thr187
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  180-190/606
• Subcellular location
  Cytoplasm
• Source
  KLH conjugated synthetic phosphopeptide derived from human TAK1 around the phosphorylation site of Thr187
• Gene ID number
  6885
• Swiss Prot
  O43318
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  TAK1; MEKK7; TGF1a; Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1; MAP3K7
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TAK1   Thr187  
• Gene symbol
  MAP3K7, NR2C2
• Short name
  Anti-TAK1 Thr187
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  TAK1(Thr187) Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6859
• Gene
  MAP3K7
• Long gene name
  mitogen-activated protein kinase kinase kinase 7
• Synonyms gene
  • TAK1
• Synonyms
  • MEKK7
• Synonyms name
  • TGF-beta activated kinase 1
• GenBank acession
  • AB009356
• Locus
  6q15
• Discovery year
  1998-05-22
• Entrez gene record
  6885
• Pubmed identfication
  • 9466656
• RefSeq identity
  • NM_145331
• Classification
  • Mitogen-activated protein kinase kinase kinases
• VEGA ID
  OTTHUMG00000015217
• Locus Specific Databases
  • The Globin Gene Server

Gene info

• Identity
  HGNC:7972
• Gene
  NR2C2
• Long gene name
  nuclear receptor subfamily 2 group C member 2
• Synonyms gene
  • TR4
• Synonyms gene name
  • nuclear receptor subfamily 2, group C, member 2
• Synonyms
  • TAK1
  • TR2R1
  • hTAK1
• GenBank acession
  • L27586
• Locus
  3p25.1
• Discovery year
  1998-05-15
• Entrez gene record
  7182
• Pubmed identfication
  • 8661150
  • 8016112
• RefSeq identity
  • NM_003298
• Classification
  • Nuclear receptor subfamily 2 group C
• VEGA ID
  OTTHUMG00000129839

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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