Syk Antibody

• Catalog number
  F44546-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Syk
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the Syk antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This Syk antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P48025
• Purity
  Antigen affinity
• Description
  Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-342 and Tyr-346. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion. Phosphorylates USP25 and regulates its intracellular levels (By similarity).
• Immunogen
  A portion of amino acids 195-223 from the mouse protein was used as the immunogen for this Syk antibody.
• Storage
  Aliquot the Syk antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Syk  
• Gene symbol
  SYK
• Short name
  Anti-Syk
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to Syk
• Alternative technique
  antibodies
• Alternative to gene target
  spleen tyrosine kinase, p72-Syk, SYK and IDBG-75571 and ENSG00000165025 and 6850, transferase activity, Plasma membranes, Syk and IDBG-152695 and ENSMUSG00000021457 and 20963, SYK and IDBG-637026 and ENSBTAG00000004767 and 515515

Gene info

• Identity
  HGNC:11491
• Gene
  SYK
• Long gene name
  spleen associated tyrosine kinase
• Synonyms gene name
  • spleen tyrosine kinase
• GenBank acession
  • L28824
• Locus
  9q22.2
• Discovery year
  1994-12-13
• Entrez gene record
  6850
• Pubmed identfication
  • 8082894
  • 1423621
• Classification
  • Syk family tyrosine kinases
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000020200

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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