SP-D/Pulmonary surfactant-associated protein D
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Catalog number
E21-541
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Price
Please ask
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Size
10ug
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Shipping_Temperature
Ambient
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Product_State
Lyophilized
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Formulation_Description
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
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Storage
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Reconstitution
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
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Purity
Greater than 95% as determined by reducing SDS-PAGE.
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Endotoxin
Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
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Background
Surfactant Pulmonary-Associated Protein D (SP-D) is a 43 kDa member of the collectin family of innate immune modulators. Its principal components consist of a collagen-like region and a C-terminal carbohydrate recognition domain (CRD), a structure that places it in a subset of pattern recognition proteins termed defense collagens. SP-D is constitutively secreted by alveolar lining cells and epithelium associated with tubular structures and induced in cardiac smooth muscle and endothelial cells. It binds both secreted and transmembrane proteins that transduce its function. It binds human neutrophil defensins, modulating influenza anti-viral defense. It binds MD-2/LY96, a secreted protein that cooperates with Toll-like receptors (TLRs) in the response of macrophages to bacterial lipopolysaccharides (LPS) or cell wall components. It also binds macrophage CD14 and TLRs directly, blocking binding of LPS and down-regulating TNF-α secretion. SP-D binding of both SIRPα and the calreticulin/CD91 complex on macrophages allows for a graded response to environmental challenge.
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Alternative Names
Pulmonary Surfactant-Associated Protein D; PSP-D; SP-D; Collectin-7; Lung Surfactant Protein D; SFTPD; COLEC7; PSPD; SFTP4
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Expression system
Human cells
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Gene target
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Gene symbol
SFTPD, SFTPA1, HOXD13, SNAR-D, REXO5, SPATA1, SPESP1, SFTA2
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Short name
SP-D/Pulmonary surfactant-associated protein D
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Species
Human
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Alternative name
SP-D/Pulmonary surfactant-associated protein D
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Gene info
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Identity
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Gene
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Long gene name
surfactant protein D
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Synonyms gene
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Synonyms gene name
- surfactant, pulmonary-associated protein D
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Synonyms
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GenBank acession
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Locus
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Discovery year
1992-06-26
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Entrez gene record
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Pubmed identfication
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Classification
- Collectins
- C-type lectin domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
surfactant protein A1
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Synonyms gene
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Synonyms gene name
- surfactant, pulmonary-associated protein A1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2001-06-22
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Entrez gene record
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RefSeq identity
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Classification
- Collectins
- C-type lectin domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
homeobox D13
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Synonyms gene
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Synonyms gene name
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1991-05-08
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Entrez gene record
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Pubmed identfication
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Classification
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VEGA ID
Gene info
Gene info
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Identity
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Gene
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Long gene name
RNA exonuclease 5
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Synonyms
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GenBank acession
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Locus
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Discovery year
2017-03-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
Gene info
Gene info
Gene info
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Identity
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Gene
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Long gene name
surfactant associated 2
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Synonyms gene
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Synonyms gene name
- surfactant associated protein G
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Synonyms
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GenBank acession
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Locus
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Discovery year
2002-05-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
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