SMAD1 Antibody

• Catalog number
  PB9395
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  SMAD1
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human, mouse, rat
• Analyses
  WB
• Immunogen
  A synthetic peptide corresponding to a sequence in the middle region of human SMAD1 (240-270aa QPMDTNMMAPPLPSEINRGDVQAVAYEEPKH), different from the related mouse sequence by two amino acids, and from the related rat sequence by five amino acids.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the SMAD1 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The SMAD1 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  SMADs are proteins that modulate the activity of transforming growth factor beta ligands. The SMADs, often in complex with other SMADs/CoSMAD, act as transcription factors that regulate the expression of certain genes. It was concluded that targeted ubiquitination of SMADs may serve to control both embryonic development and a wide variety of cellular responses to TGF-beta signals. R-Smads or receptor regulated Smads are a class of proteins that include SMAD1, SMAD2, SMAD3, SMAD5, and SMAD8. In response to signals by the TGF-β superfamily of ligands these proteins associate with receptor kinases and are phosphorylated at an SSXS motif at their extreme C-terminus. These proteins then typically bind to the common mediator Smad or co-SMAD SMAD4.
• Related articles
  1. Zhu, H., Kavsak, P., Abdollah, S., Wrana, J. L., Thomsen, G. H. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400: 687-693, 1999.
• Gene Name
  SMAD1
• Protein Name
  Mothers against decapentaplegic homolog 1
• Gene Full Name
  SMAD family member 1
• Synonyms
  BSP 1 | BSP1 | BSP-1 | BSP1 | MADH1 | MADR1 | HsMAD1 | JV4 1 | JV4-1 | MADH1 | Madh1 | Madr1 | Q15797 | SMAD1
• Uniprot ID
  Q15797
• Entrez GeneID
  4086
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SMAD1  
• Gene symbol
  SMAD1-AS2, SMAD1-AS1, SMAD1, GARS1
• Short name
  SMAD1 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  SMAD family member 1 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  SMAD family member 1, BSP-1 and BSP1 and JV4-1 and JV41 and MADH1 and MADR1, SMAD1 and IDBG-39936 and ENSG00000170365 and 4086, transforming growth factor beta receptor, nuclei, Smad1 and IDBG-170516 and ENSMUSG00000031681 and 17125, SMAD1 and IDBG-629431 and ENSBTAG00000002835 and 540488

Gene info

• Identity
  HGNC:49381
• Gene
  SMAD1-AS2
• Long gene name
  SMAD1 antisense RNA 2
• GenBank acession
  • BC042377
• Locus
  4q31.21
• Discovery year
  2013-10-22
• Entrez gene record
  101927659
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000162185

Gene info

• Identity
  HGNC:49379
• Gene
  SMAD1-AS1
• Long gene name
  SMAD1 antisense RNA 1
• Synonyms
  • ENST00000513542
• GenBank acession
  • AW087665
• Locus
  4q31.21
• Discovery year
  2013-10-22
• Pubmed identfication
  • 24147006
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000162186

Gene info

• Identity
  HGNC:6767
• Gene
  SMAD1
• Long gene name
  SMAD family member 1
• Synonyms gene
  • MADH1
• Synonyms gene name
  • MAD, mothers against decapentaplegic homolog 1 (Drosophila)
  • SMAD, mothers against DPP homolog 1 (Drosophila)
• Synonyms
  • MADR1
  • JV4-1
• GenBank acession
  • U59423
• Locus
  4q31.21
• Discovery year
  1996-11-15
• Entrez gene record
  4086
• Pubmed identfication
  • 8653785
  • 8673135
• RefSeq identity
  • NM_005900
• Classification
  • SMAD family
• VEGA ID
  OTTHUMG00000161592

Gene info

• Identity
  HGNC:4162
• Gene
  GARS1
• Long gene name
  glycyl-tRNA synthetase 1
• Synonyms gene
  • CMT2D
  • GARS
• Synonyms gene name
  • Charcot-Marie-Tooth neuropathy 2D
  • glycyl-tRNA synthetase
• Synonyms
  • GlyRS
  • DSMAV
  • SMAD1
• Synonyms name
  • glycine tRNA ligase
• GenBank acession
  • AK074524
• Locus
  7p14.3
• Discovery year
  1995-03-21
• Entrez gene record
  2617
• Pubmed identfication
  • 8595897
  • 8872480
• RefSeq identity
  • NM_002047
• Classification
  • Aminoacyl tRNA synthetases, Class II
• VEGA ID
  OTTHUMG00000152769
• Locus Specific Databases
  • Inherited Peripheral Neuropathies Mutation Database
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database
  • LRG_243

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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