SLC12A6 Antibody
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Catalog numberPA2171
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PricePlease ask
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Size0,1 mg
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Target antigenSLC12A6
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ClonalityPolyclonal antibody
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ClonePolyclonal antibody
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Raised inrabbit
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Type of the antibodyIgG polyclonal antibody
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Product formfreeze-dried
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Reacts with specieshuman, rat Predicted to work with: mouse
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AnalysesWB
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ImmunogenA synthetic peptide corresponding to a sequence at the C-terminus of human SLC12A6(1060-1080aa QKAKSMEGFQDLLNMRPDQSN), different from the related mouse and rat sequences by one amino acid.
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Product configurationEach vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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PurificationImmunogen affinity purified.
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SolubilizationThe powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtionsKeep the SLC12A6 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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TipsThe SLC12A6 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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BackgroundSolute carrier family 12(potassium/chloride transporters), member 6, also called SLC12A6 or KCC3, is a protein that in humans is encoded by the SLC12A6 gene. This gene is a member of the K-Cl cotransporter(KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. By radiation hybrid and somatic cell hybrid analyses, this gene is mapped to 15q14. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.
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Related articles1. Howard, H. C., Mount, D. B., Rochefort, D., Byun, N., Dupre, N., Lu, J., Fan, X., Song, L., Riviere, J.-B., Prevost, C., Horst, J., Simonati, A., and 12 others. The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. Nature Genet. 32: 384-392, 2002. Note: Erratum: Nature Genet. 32: 681 only, 2002. 2. Salin-Cantegrel, A., Riviere, J.-B., Shekarabi, M., Rasheed, S., DaCal, S., Laganiere, J., Gaudet, R., Rochefort, D., Lesca, G., Gaspar, C., Dion, P. A., Lapointe, J.-Y., Rouleau, G. A.Transit defect of potassium-chloride co-transporter 3 is a major pathogenic mechanism in hereditary motor and sensory neuropathy with agenesis of the corpus callosum. J. Biol. Chem. 286: 28456-28465, 2011.
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Gene NameSLC12A6
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Protein NameSolute carrier family 12 member 6
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Gene Full Namesolute carrier family 12(potassium/chloride transporters), member 6
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SynonymsACCPN antibody|Furosemide sensitive KCl cotransporter 3 antibody|Gaxp antibody|KCC 3 antibody|KCC 3A antibody|KCC 3B antibody|KCC3 A antibody|KCC3 antibody|KCC3 B antibody|KCC3A antibody|KCC3B antibody|Potassium chloride cotransporter 3 antibody|Potassium chloride cotransporter KCC3a S3 antibody|SLC12 A6 antibody|SLC12A 6 antibody|Solute carrier family 12(potassium/chloride transporters), member 6 antibody|Solute carrier family 12, member 6 antibody
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Uniprot IDQ9UHW9
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PropertiesIf you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolSLC12A6
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Short nameSLC12A6 Antibody
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TechniqueAntibody, antibodies against human proteins, antibodies for
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Alternative nameSLC12A6 (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namesolute carrier family 12 member 6
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Synonyms gene
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Synonyms gene name
- agenesis of corpus callosum and peripheral neuropathy (Andermann syndrome)
- solute carrier family 12 (potassium/chloride transporter), member 6
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GenBank acession
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Locus
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Discovery year1999-05-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Solute carriers
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data