SC-26196
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Catalog numberB1580-25
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Price625.25 USD
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Size25 mg
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Alternative_name2,2-diphenyl-5-[4-(pyridin-3-ylmethylideneamino)piperazin-1-yl]pentanenitrile
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DescriptionSC-26196 is a selective Δ6 desaturase inhibitor (IC₅₀ = 0.2 μM in vitro. It displays selectivity over Δ5 and Δ9 desaturases (IC₅₀ values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro. SC-26196 is orally active in vivo, decreasing edema in the carrageenan paw edema model in mice.
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CAS Number218136-59-5
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Structure AvailableYes
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Molecular FormulaC₂₇H₂₉N₅
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Molecular Weight423.55
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (~10 mg/ml)
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HandlingProtect from air and light
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Tag LineA selective Δ6 desaturase inhibitor
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Storage Condition-20°C
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Shipping ConditionGel Pack
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Shelf Life36 months
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MDL NumberMFCD11226148
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PubChem CID9845201
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SMILESC1CN(CCN1CCCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)N=CC4=CN=CC=C4
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InChiC1CN(CCN1CCCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)/N=C/C4=CN=CC=C4
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InChi KeyQFYKXKMYVYOUNJ-JBASAIQMSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolERMAP, SRSF2
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Short nameSC-26196
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Alternative nameSC-26196
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Gene info
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Identity
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Gene
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Long gene nameerythroblast membrane associated protein (Scianna blood group)
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Synonyms gene
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Synonyms gene name
- Radin blood group
- Scianna blood group
- erythroblast membrane-associated protein
- erythroblast membrane-associated protein (RD and SC blood groups)
- erythroblast membrane-associated protein (Scianna blood group)
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-09-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- V-set domain containing
- Butyrophilins
- Blood group antigens
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameserine and arginine rich splicing factor 2
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Synonyms gene
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Synonyms gene name
- splicing factor, arginine/serine-rich 2
- serine/arginine-rich splicing factor 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1993-09-17
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Serine and arginine rich splicing factors
- RNA binding motif containing
- MicroRNA protein coding host genes
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VEGA ID
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Locus Specific Databases