Recombinant Mouse Epcr / PROCR Protein (Fc tag)

• Catalog number
  PKSM040454-20µg
• Price
  Please ask
• Size
  20µg

• Synonym
  AI325044;Ccca;Ccd41;Epcr
• Activity
  NA
• Sequence
  Met 1-Ser 214
• Fusion tag
  C-Fc
• Accession
  Q64695
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 85 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  49.3 kDa
• AP Mol Mass
  65-75 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other. 
• Technical data
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Epcr   PROCR   Protein   tag  
• Gene symbol
  PROCR
• Short name
  Recombinant Mouse Epcr / PROCR Protein (Fc tag)
• Technique
  Recombinant, Mouse, FC, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  mouse
• Label
  Fc Tag
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse Epcr / protein C receptor, endothelial Protein (fragment c detection labelled)
• Alternative technique
  rec, murine
• Alternative to gene target
  protein C receptor, endothelial, CCCA and CCD41 and EPCR, PROCR and IDBG-69466 and ENSG00000101000 and 10544, protein binding, Plasma membranes, Procr and IDBG-210683 and ENSMUSG00000027611 and 19124, PROCR and IDBG-642142 and ENSBTAG00000008291 and 282005

Gene info

• Identity
  HGNC:9452
• Gene
  PROCR
• Long gene name
  protein C receptor
• Synonyms gene name
  • protein C receptor, endothelial
• Synonyms
  • EPCR
  • CCD41
  • CD201
• GenBank acession
  • L35545
• Locus
  20q11.22
• Discovery year
  2000-06-26
• Entrez gene record
  10544
• Pubmed identfication
  • 7929370
  • 10518938
• Classification
  • CD molecules
• VEGA ID
  OTTHUMG00000032323
• Locus Specific Databases
  • LRG_638

MeSH Data

• Name
  Polymerase Chain Reaction
• Concept
  Scope note: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
• Tree numbers
  • E05.393.620.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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