Recombinant Human TrkC / NTRK3 Protein (His & Fc tag)

• Catalog number
  PKSH031916-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  gp145(trkC);TRKC
• Activity
  Immobilized human TrKc-Fch at 10 μg/ml (100 μl/well) can bind biotinylated human NT3, The EC50 of biotinylated human NT3 is 23.4-54.6 ng/ml.
• Sequence
  Met1-Asp428
• Fusion tag
  C-His & Fc
• Accession
  NP_001007157.1
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞98 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  72.5 kDa
• AP Mol Mass
  110-120 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  NT-3 growth factor receptor also known as neurotrophic tyrosine kinase receptor type 3 or TrkC tyrosine kinase or Trk-C receptor, is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkC/NTRK3 is widely expressed in the developing and adult nervous system. In later embryonic development, TrkC/NTRK3 is expressed in various structures of the CNS including the caudatoputamen, septal nuclei, cerebellum, and brainstem. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. In the PNS, trkC hybridization appears to correlate, both temporally and spatially, with the outgrowth of axons toward their peripheral targets. TrkC/NTRK3 is widely expressed in the three identified branches of the mammalian nervous system and appears to correlate with the expression of NT-3, its cognate ligand. The apparent colocalization of trkC transcripts with NT-3 raises the possibility this neurotrophin exerts its trophic effects by a paracrine and/or autocrine mechanism. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in TrkC encoding gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy
• Technical data
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  TrkC   NTRK3   Protein   His   tag  
• Gene symbol
  NTRK3-AS1, NTRK3
• Short name
  Recombinant TrkC / NTRK3 Protein (His & Fc tag)
• Technique
  Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens TrkC / NTRK3 Protein (histidine & fragment c detection labelled)
• Alternative technique
  rec

Gene info

• Identity
  HGNC:27532
• Gene
  NTRK3-AS1
• Long gene name
  NTRK3 antisense RNA 1
• Synonyms gene name
  • NTRK3 antisense RNA 1 (non-protein coding)
• GenBank acession
  • AK097486
• Locus
  15q25.3
• Discovery year
  2012-06-30
• Entrez gene record
  283738
• RefSeq identity
  • NR_038229
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000173016

Gene info

• Identity
  HGNC:8033
• Gene
  NTRK3
• Long gene name
  neurotrophic receptor tyrosine kinase 3
• Synonyms gene name
  • neurotrophic tyrosine kinase, receptor, type 3
• Synonyms
  • TRKC
• GenBank acession
  • U05012
• Locus
  15q25.3
• Discovery year
  1991-07-18
• Entrez gene record
  4916
• Pubmed identfication
  • 7806211
• Classification
  • I-set domain containing
  • Receptor tyrosine kinases
• VEGA ID
  OTTHUMG00000148677

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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