Recombinant Human SOD1 / Superoxide Dismutase Protein (His tag) 100µg

• Catalog number
  PKSH031023-100µg
• Price
  Please ask
• Size
  100µg

• Synonym
  ALS;ALS1;HEL-S-44;homodimer;hSod1;IPOA;SOD
• Activity
  NA
• Sequence
  Ala 2-Gln 154
• Fusion tag
  N-His
• Accession
  NP_000445.1
• Expressed Host
  E. coli
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞97 % as determined by SDS-PAGE
• Endotoxin
  Please contact us for more information.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  16.8 kDa
• AP Mol Mass
  20 kDa
• Formulation
  Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0
• Reconstitution
  Please refer to it for detailed information.
• Background
  SOD1 belongs to the Cu-Zn superoxide dismutase family. It binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. SOD1 destroys radicals which are normally produced within the cells and which are toxic to biological systems. Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1). ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.
• Product URL
• PDF URL
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  SOD1   Superoxide   Dismutase   Protein   His   tag   100µg  
• Gene symbol
  SOD1-DT, SOD1
• Short name
  Recombinant SOD1 / Superoxide Dismutase Protein (His tag) 100µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens superoxide dismutase 1, soluble / Superoxide Dismutase Protein (histidine detection labelled) 100µg
• Alternative technique
  rec
• Alternative to gene target
  superoxide dismutase 1, soluble, ALS and ALS1 and HEL-S-44 and homodimer and hSod1 and IPOA and SOD, SOD1 and IDBG-1609 and ENSG00000142168 and 6647, chaperone binding, nuclei, Sod1 and IDBG-174662 and ENSMUSG00000022982 and 20655

Gene info

• Identity
  HGNC:55683
• Gene
  SOD1-DT
• Long gene name
  SOD1 divergent transcript
• Locus
  21q22.11
• Discovery year
  2021-07-01
• Entrez gene record
  102724449
• Classification
  • Divergent transcripts

Gene info

• Identity
  HGNC:11179
• Gene
  SOD1
• Long gene name
  superoxide dismutase 1
• Synonyms gene
  • ALS
  • ALS1
• Synonyms gene name
  • amyotrophic lateral sclerosis 1 (adult)
  • superoxide dismutase 1, soluble
• Synonyms
  • IPOA
• GenBank acession
  • AY049787
  • X02317
• Locus
  21q22.11
• Discovery year
  1986-01-01
• Entrez gene record
  6647
• Pubmed identfication
  • 8446170
• RefSeq identity
  • NM_000454
• Classification
  • Superoxide dismutases
• VEGA ID
  OTTHUMG00000084878
• Locus Specific Databases
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database
  • LRG_652

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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