Recombinant Human KLK-1 / Kallikrein-1 Protein (His tag)

#

• Catalog number
  PKSH031628-10µg
• Price:

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• Size
  10µg

# #

• Synonym
  hK1;Klk6;KLKR
• Activity
  Measured by its ability to cleave a flourogenic peptide substrate Pro-Phe-Arg-7-amido-4-methylcoumarin (PFR-AMC). The specific activity is >1,500 pmoles/min/μg.(Activation description: The proenzyme needs to be activated by Thermolysin for an activated form)
• Sequence
  Met 1-Ser 262
• Fusion tag
  C-His
• Accession
  NP_002248.1
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 95 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  28 kDa
• AP Mol Mass
  28 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Human tissue kallikrein (KLK1) is a serine protease, component of the KKS that has been demonstrated to exert pleiotropic beneficial effects in protection from tissue injury through its antiinflammatory, antiapoptotic, antifibrotic and antioxidative actions.Polymorphism of the human tissue kallikrein 1 (KLK1) A1789G gene is associated with susceptibility to hypertension.
• Technical data
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

#

• Gene target
  KLK-1   Kallikrein-1   Protein   His   tag  
• Gene symbol
  KLK1, KLK14, KLK12, KLK9, KLK13, KLK5, KLK4, IGHVII-1-1, MIR1-1, TRUND-NNN8-1
• Short name
  Recombinant KLK-1 / Kallikrein-1 Protein (His tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens KLK-1 / Kallikrein-1 Protein (histidine detection labelled)
• Alternative technique
  rec

Gene info

• Identity
  HGNC:6357
• Gene
  KLK1
• Long gene name
  kallikrein 1
• Synonyms gene name
  • kallikrein 1, renal/pancreas/salivary
• Synonyms
  • Klk6
• GenBank acession
  • L10038
• Locus
  19q13.33
• Discovery year
  1988-06-27
• Entrez gene record
  3816
• Pubmed identfication
  • 1684954
  • 16800724
  • 16800723
• RefSeq identity
  • NM_002257
• Classification
  • Kallikreins
• VEGA ID
  OTTHUMG00000182876

Gene info

• Identity
  HGNC:6362
• Gene
  KLK14
• Long gene name
  kallikrein related peptidase 14
• Synonyms gene name
  • kallikrein 14
• Synonyms
  • KLK-L6
• GenBank acession
  • AF283670
• Locus
  19q13.41
• Discovery year
  2000-03-16
• Entrez gene record
  43847
• Pubmed identfication
  • 16800724
  • 16800723
• RefSeq identity
  • NM_022046
• Classification
  • Kallikreins
• VEGA ID
  OTTHUMG00000143721

Gene info

• Identity
  HGNC:6360
• Gene
  KLK12
• Long gene name
  kallikrein related peptidase 12
• Synonyms gene name
  • kallikrein 12
• Synonyms
  • KLK-L5
• Locus
  19q13.41
• Discovery year
  2000-03-16
• Entrez gene record
  43849
• Pubmed identfication
  • 16800724
  • 16800723
• RefSeq identity
  • NM_019598
• Classification
  • Kallikreins
• VEGA ID
  OTTHUMG00000165806

Gene info

• Identity
  HGNC:6370
• Gene
  KLK9
• Long gene name
  kallikrein related peptidase 9
• Synonyms gene name
  • kallikrein 9
• Synonyms
  • KLK-L3
• GenBank acession
  • AF135026
• Locus
  19q13.41
• Discovery year
  2000-03-16
• Entrez gene record
  284366
• Pubmed identfication
  • 16800724
  • 16800723
• RefSeq identity
  • NM_012315
• Classification
  • Kallikreins
• VEGA ID
  OTTHUMG00000183087

Gene info

• Identity
  HGNC:6361
• Gene
  KLK13
• Long gene name
  kallikrein related peptidase 13
• Synonyms gene name
  • kallikrein 13
• Synonyms
  • KLK-L4
• Locus
  19q13.41
• Discovery year
  2000-03-16
• Entrez gene record
  26085
• Pubmed identfication
  • 16800724
  • 16800723
• RefSeq identity
  • NM_015596
• Classification
  • Kallikreins
• VEGA ID
  OTTHUMG00000182912

Gene info

• Identity
  HGNC:6366
• Gene
  KLK5
• Long gene name
  kallikrein related peptidase 5
• Synonyms gene name
  • kallikrein 5
• Synonyms
  • SCTE
  • KLK-L2
• GenBank acession
  • AF135028
• Locus
  19q13.41
• Discovery year
  2000-03-16
• Entrez gene record
  25818
• Pubmed identfication
  • 10514489
  • 10608802
  • 16800724
  • 17012259
• RefSeq identity
  • NM_012427
• Classification
  • Kallikreins
• VEGA ID
  OTTHUMG00000183097

Gene info

• Identity
  HGNC:6365
• Gene
  KLK4
• Long gene name
  kallikrein related peptidase 4
• Synonyms gene
  • PRSS17
• Synonyms gene name
  • kallikrein 4 (prostase, enamel matrix, prostate)
• Synonyms
  • EMSP
  • EMSP1
  • PSTS
  • KLK-L1
• Synonyms name
  • enamel matrix serine proteinase 1
• GenBank acession
  • AF113141
• Locus
  19q13.41
• Discovery year
  1999-04-29
• Entrez gene record
  9622
• Pubmed identfication
  • 10077646
  • 10438493
  • 16800724
  • 10863090
  • 9465170
• RefSeq identity
  • NM_004917
• Classification
  • Kallikreins
  • Serine proteases
• VEGA ID
  OTTHUMG00000182964

Gene info

• Identity
  HGNC:5670
• Gene
  IGHVII-1-1
• Long gene name
  immunoglobulin heavy variable (II)-1-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (II)-1-1
  • immunoglobulin heavy variable (II)-1-1 pseudogene
• Synonyms
  • IGHV(II)-1-1
• GenBank acession
  • AB019441
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28377
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152325

Gene info

• Identity
  HGNC:31499
• Gene
  MIR1-1
• Long gene name
  microRNA 1-1
• Synonyms gene
  • MIRN1-1
• Synonyms
  • hsa-mir-1-1
• Locus
  20q13.33
• Discovery year
  2004-04-23
• Entrez gene record
  406904
• RefSeq identity
  • NR_029780
• Classification
  • MicroRNA MIR1/206 family

Gene info

• Identity
  HGNC:50820
• Gene
  TRUND-NNN8-1
• Long gene name
  tRNA-undetermined (NNN) 8-1
• Synonyms gene name
  • transfer RNA-undetermined (NNN) 8-1
• GenBank acession
  • HG984097
• Locus
  1
• Discovery year
  2014-06-20
• Entrez gene record
  103482528
• Pubmed identfication
  • 18984615

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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