Recombinant Human KIR2DL1 / CD158a Protein (Fc tag)
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Catalog number
PKSH030712-20µg
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Price
Please ask
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Size
20µg
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Synonym
CD158A;KIR-K64;KIR221;NKAT;NKAT-1;NKAT1;p58.1;XXbac-BCX195L8.1;XXbac-BPG184J6.7
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Activity
NA
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Sequence
Met 1-His 245
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Fusion tag
C-Fc
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Accession
NP_055033.2
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Expressed Host
HEK293 Cells
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Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity
＞90 % as determined by SDS-PAGE
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Endotoxin
＜1.0 EU per µg as determined by the LAL method
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Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass
51.7 kDa
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AP Mol Mass
70 kDa
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Formulation
Lyophilized from sterile PBS, pH 7.4
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Background
Killer cell immunoglobulin-like receptor 2DL1 or KIR2DL1 is an inhibitory natural Killer cell immunoglobulin-like receptor with two extracellular immunoglobulin domains. KIR2DL1 is a member of the Killer cell immunoglobulin-like receptor family whose members are classified by the number of the extracellular immunoglobulin domains and the length of the cytoplasm domain. KIR2DL1 is a transmembrane glycoprotein expressed by natural killer cells and subsets of T cells. KIR2DL1 down-regulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. It has been reported that the KIR2DL1 bound to its class I MHC ligand, HLA-Cw4. The KIR2DL1-HLA-Cw4 interface exhibits charge and shape complementarity. Specificity is mediated by a pocket in KIR2DL1 that hosts the Lys80 residue of HLA-Cw4. Many residues conserved in HLA-C and in KIR2DL receptors make different interactions in KIR2DL1-HLA-Cw4 and in a previously reported KIR2DL2-HLA-Cw3 complex. A dimeric aggregate of KIR-HLA-C complexes was observed in one KIR2DL1-HLA-Cw4 crystal.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
KIR2DL1
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Short name
Recombinant KIR2DL1 / CD158a Protein (Fc tag)
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Technique
Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Label
Fc Tag
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Species
Human, Humans
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Alternative name
Rec. H. sapiens killer cellular immunoglobulin-like receptor, two domains, large cytoplasmic tail, 1 / CD158a Protein (fragment c detection labelled)
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Alternative technique
rec
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Alternative to gene target
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1, CD158A and KIR-K64 and KIR221 and NKAT and NKAT-1 and NKAT1 and p58.1, KIR2DL1 and IDBG-68931 and ENSG00000125498 and 3802, protein binding, Plasma membranes
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Gene info
MeSH Data
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Name
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Concept
Scope note:
Electrophoresis in which a second perpendicular electrophoretic transport is performed on the separate components resulting from the first electrophoresis. This technique is usually performed on polyacrylamide gels.
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Tree numbers
- E05.196.401.250
- E05.301.300.230
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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