Recombinant Human HER3 / ErbB3 Protein (His tag) 20µg

• Catalog number
  PKSH031766-20µg
• Price
  Please ask
• Size
  20µg

• Synonym
  c-erbB-3;c-erbB3;EEBB3;ErbB-3;erbB3-S;HER3;LCCS2;MDA-BF-1;p180-ErbB3;p45-sErbB3;p85-sErbB3
• Activity
  Measured by its binding ability in a functional ELISA.2. Immobilized human ErbB3 at 2 μg/mL (100 μl/well) can bind human NRG1 (isoform Beta1), The EC50 of human NRG1 (isoform Beta1) is 0.43 μg/mL.
• Sequence
  Met 1-Thr 643
• Fusion tag
  C-His
• Accession
  NP_001973.2
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞95 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  70.2 kDa
• AP Mol Mass
  100-110 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.5
• Reconstitution
  Please refer to it for detailed information.
• Background
  ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy
• Product URL
• PDF URL
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  HER3   ErbB3   Protein   His   tag   20µg  
• Gene symbol
  ERBB3
• Short name
  Recombinant HER3 / ErbB3 Protein (His tag) 20µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens HER3 / v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) Protein (histidine detection labelled) 20µg
• Alternative technique
  rec
• Alternative to gene target
  v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), c-erbB-3 and c-erbB3 and ErbB-3 and erbB3-S and HER3 and LCCS2 and MDA-BF-1 and p180-ErbB3 and p45-sErbB3 and p85-sErbB3, ERBB3 and IDBG-39824 and ENSG00000065361 and 2065, transferase activity, Extracellular, Erbb3 and IDBG-197943 and ENSMUSG00000018166 and 13867, ERBB3 and IDBG-636302 and ENSBTAG00000010444 and 785655

Gene info

• Identity
  HGNC:3431
• Gene
  ERBB3
• Long gene name
  erb-b2 receptor tyrosine kinase 3
• Synonyms gene
  • LCCS2
• Synonyms gene name
  • lethal congenital contracture syndrome 2
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
• Synonyms
  • HER3
• Synonyms name
  • human epidermal growth factor receptor 3
• GenBank acession
  • M34309
• Locus
  12q13.2
• Discovery year
  1990-07-15
• Entrez gene record
  2065
• RefSeq identity
  • NM_001982
• Classification
  • Erb-b2 receptor tyrosine kinases
• VEGA ID
  OTTHUMG00000170140
• Locus Specific Databases
  • LRG_996

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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