Recombinant Human CD171 / N-CAML1 / L1CAM Protein (His tag) 200µg
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Catalog numberPKSH031838-200µg
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PricePlease ask
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Size200µg
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SynonymCAML1;CD171;HSAS;HSAS1;MASA;MIC5;N-CAM-L1;N-CAML1;NCAM-L1;S10;SPG1
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ActivityNA
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SequenceMet 1-Glu 1120
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Fusion tagC-His
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AccessionNP_000416.1
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Expressed HostHEK293 Cells
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ShippingIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity>85 % as determined by SDS-PAGE
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Endotoxin<1.0 EU per µg as determined by the LAL method
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Stability and StorageSamples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass125 kDa
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AP Mol Mass160-200 kDa
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FormulationLyophilized from sterile PBS, pH 7.4
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ReconstitutionPlease refer to it for detailed information.
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BackgroundL1 cell adhesion molecule (L1CAM), also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and in a variety of cancer cells, including some common types of human cancer. L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan and intergrins, and it has been revealed that the RGD motif in the sixth Ig domain of L1CAM is a binding site for integrins, thus important for nuclear signaling. Disruption of L1CAM function causes three X-linked neurological syndromes, i.e. hydrocephalus, MASA syndrome (mental retardation, aphasia, shuffling gait and adducted thumbs) and spastic paraplegia syndrome. Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate and promoted cell transformation and tumorigenicity. Recent work has identified L1CAM (CD171) as a novel marker for human carcinoma progression, and a candidate for anti-cancer therapy.
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Conjugationhistidine
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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SourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolL1CAM, L1CAM-AS1, GH1, POLM, NRAS, SDC3, PIGN, WASL, MAP6, HLA-N
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Short nameRecombinant CD171 / N-CAML1 / L1CAM Protein (His tag) 200µg
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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LabelHis
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SpeciesHuman, Humans
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Alternative nameRec. H. sapiens CD171 / N-CAML1 / L1 cellular adhesion molecule Protein (histidine detection labelled) 200µg
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Alternative techniquerec
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Alternative to gene targetL1 cell adhesion molecule, CAML1 and CD171 and HSAS and HSAS1 and MASA and MIC5 and N-CAM-L1 and N-CAML1 and NCAM-L1 and S10 and SPG1, L1CAM and IDBG-90096 and ENSG00000198910 and 3897, protein self-association, Cell surfaces, L1cam and IDBG-154012 and ENSMUSG00000031391 and 16728, L1CAM and IDBG-632479 and ENSBTAG00000013462 and 516017
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Gene info
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Identity
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Gene
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Long gene nameL1 cell adhesion molecule
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Synonyms gene
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Synonyms gene name
- antigen identified by monoclonal antibody R1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1989-06-30
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Entrez gene record
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RefSeq identity
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Classification
- Ig-like cell adhesion molecule family
- I-set domain containing
- Fibronectin type III domain containing
- CD molecules
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameL1CAM antisense RNA 1
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Synonyms
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Synonyms name
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Locus
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Discovery year2021-09-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
Gene info
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Identity
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Gene
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Long gene namegrowth hormone 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Growth hormone family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameDNA polymerase mu
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Synonyms gene name
- polymerase (DNA directed), mu
- polymerase (DNA) mu
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2000-02-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- DNA polymerases
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameNRAS proto-oncogene, GTPase
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Synonyms gene name
- neuroblastoma RAS viral (v-ras) oncogene homolog
- neuroblastoma RAS viral oncogene homolog
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- RAS type GTPase family
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namesyndecan 3
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Synonyms gene name
- syndecan 3 (N-syndecan)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1994-05-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Syndecans
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namephosphatidylinositol glycan anchor biosynthesis class N
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Synonyms gene name
- phosphatidylinositol glycan, class N
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-05-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Phosphatidylinositol glycan anchor biosynthesis
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameWASP like actin nucleation promoting factor
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Synonyms gene name
- Wiskott-Aldrich syndrome-like
- Wiskott-Aldrich syndrome like
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-10-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Wiskott-Aldrich Syndrome protein family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicrotubule associated protein 6
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-02-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class I, N (pseudogene)
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-10-23
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Histocompatibility complex
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data