Recombinant Aggrecan Interglobular Domain (ACAN-IGD) (Recombinant Protein)

• Catalog number
  30 411 004
• Price
  Please ask
• Size
  100 µg/ 200 µl

• Protein type
  Recombinant
• Protein subtype
  N/A
• Protein family
  Aggrecan/versican proteoglycan family.
• Protein description
  The Aggrecan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
• Research area interests
  Diseases associated with ACAN include Osteochondritis Dissecans, Short Stature, And Early-Onset Osteoarthritis and Spondyloepimetaphyseal Dysplasia, Aggrecan Type. Among its related pathways are Diseases associated with O-glycosylation of proteins and Integrin Pathway.
• Package form
  liquid
• Tested applications
  substrate for aggrecanases and matrix metalloproteinases activity measurements
• Other names
  Aggrecan Proteoglycan -IGD
• Peptide sequence
  T A E D F V D I P E N F F G V G G E E D I T V Q T V T W P D M E L P L P R N I T E G E A R G S V I L T V K P I F E V S P S P L E P E E P F T F A P E I G A T A F A E V E N E T G E A T R P W G F P T P G L G P A T A F T S E D L V V Q V T A V P G Q P H L P G G (His-tag)
• Available target modification
  No
• Expression system
  E.coli
• Product Subtype
  protein fragment
• Active form
  No
• Tag
  His-tagged
• Contents
  50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2
• Protein purity
  >80%
• Molecular weight
  21 kDa
• UniProt number
  P16112
• Gene number
  176
• Abbreviation
  ACAN (partial)
• Full name
  aggrecan (partial)
• Other desciption
  The recombinant protein contains cleavage sites for aggrecanases (E373 - A374 in human aggrecan) and matrix metalloproteinases (N341 - F342 in human aggrecan).
• Purification
  Mentioned in the data sheet
• PubMed citations
  See the data sheet
• Warnings
  For Research Use only.
• Shipping conditions
  dry ice
• Storage condition
  Store at -70°C
• Technical datasheet
  Contact us to receive the datasheet
• Representative figure
• Other products
• Properties
  Immunoglobulin D (IgD) is an antibody isotype that makes up about 1% of proteins in the plasma membranes of mature B-lymphocytes where it is usually coexpressed with another cell surface antibody called IgM. IgD is also produced in a secreted form that is found in very small amounts in blood serum, representing 0.25% of immunoglobulins in serum for virus detection. Anti-viral immunoglobulin D antibodies have a diagnostic value.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Aggrecan   Interglobular   Domain   ACAN   Protein  
• Gene symbol
  ACAN
• Short name
  Recombinant Aggrecan Interglobular Domain (ACAN-IGD) (Recombinant Protein)
• Technique
  Recombinant, IgD, IgDs, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. biotez advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Isotype
  IgD, IgD
• Species
  Homo sapiens
• Alternative name
  Rec. Aggrecan Interglobular Domain (aggrecan-IGD) (Rec. Protein)
• Alternative technique
  rec, immunoglobulin-d
• Alternative to gene target
  aggrecan, AGC1 and AGCAN and CSPG1 and CSPGCP and MSK16 and SEDK, ACAN and IDBG-28773 and ENSG00000157766 and 176, carbohydrate binding, Extracellular, Acan and IDBG-193557 and ENSMUSG00000030607 and 11595, BT.92700 and IDBG-628953 and ENSBTAG00000016158 and 280985

Gene info

• Identity
  HGNC:319
• Gene
  ACAN
• Long gene name
  aggrecan
• Synonyms gene
  • MSK16
  • CSPG1
  • AGC1
• Synonyms gene name
  • chondroitin sulfate proteoglycan 1
  • aggrecan 1
• Synonyms
  • CSPGCP
• Synonyms name
  • aggrecan proteoglycan
• GenBank acession
  • M55172
• Locus
  15q26.1
• Discovery year
  1992-06-17
• Entrez gene record
  176
• Pubmed identfication
  • 1985970
• RefSeq identity
  • NM_001135
• Classification
  • Sushi domain containing
  • Hyalectan proteoglycans
  • V-set domain containing
  • C-type lectin domain containing
• VEGA ID
  OTTHUMG00000171989

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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