RAC1 (1301CT276.121.104) Monoclonal Antibody

• Catalog number
  bsm-51282M
• Price
  Please ask
• Size
  0.1ml

• Long name
  RAC1 (1301CT276.121.104) Monoclonal Antibody
• Also known as
  RAC1 (1301CT276.121.104) Monoclonal Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  RAC1
• Specificity
  This is a highly specific antibody against RAC1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Monoclonal
• Clone number
  1301CT276.121.104
• Source
  This antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between amino acids from human.
• Gene ID number
  5879
• Swiss Prot
  P63000
• Tested Applications
  WB, FCM, IHC-P
• Recommended dilutions
  IHC-P(1:25), FC(1:100), IHC-P(1:25)
• Cross reactivity
  Human, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3. Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  MIG5; Rac-1; TC-25; p21-Rac1; Ras-related C3 botulinum toxin substrate 1; Cell migration-inducing gene 5 protein; Ras-like protein TC25; RAC1; TC25
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  RAC1   1301CT276   121   104   Monoclonal  
• Gene symbol
  RAC1, RNASE1
• Short name
  Anti-RAC1
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  Immunoglobulin G (IgG)2b
• Alternative name
  RAC1 (1301CT276.121.104) Monoclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1), p21-Rac1 and Rac-1 and TC-25, RAC1 and IDBG-8115 and ENSG00000136238 and 5879, Rho GDP-dissociation inhibitor binding, Plasma membranes, Rac1 and IDBG-207763 and ENSMUSG00000001847 and 19353, RAC1 and IDBG-641023 and ENSBTAG00000009233 and 281440

Gene info

• Identity
  HGNC:9801
• Gene
  RAC1
• Long gene name
  Rac family small GTPase 1
• Synonyms gene name
  • ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
• Synonyms
  • TC-25
  • p21-Rac1
  • Rac-1
• GenBank acession
  • AJ132695
• Locus
  7p22.1
• Discovery year
  1993-11-05
• Entrez gene record
  5879
• Pubmed identfication
  • 2674130
  • 10597294
• RefSeq identity
  • NM_018890
• Classification
  • Rho family GTPases
  • Receptor ligands
• VEGA ID
  OTTHUMG00000023540

Gene info

• Identity
  HGNC:10044
• Gene
  RNASE1
• Long gene name
  ribonuclease A family member 1, pancreatic
• Synonyms gene
  • RNS1
• Synonyms gene name
  • ribonuclease, RNase A family, 1 (pancreatic)
• Synonyms
  • RAC1
• GenBank acession
  • BC005324
• Locus
  14q11.2
• Discovery year
  1990-02-24
• Entrez gene record
  6035
• Pubmed identfication
  • 8588814
• Classification
  • Ribonuclease A family
• VEGA ID
  OTTHUMG00000029603

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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