RAB7 Antibody

• Catalog number
  bs-6703R
• Price
  Please ask
• Size
  0.1ml

• Long name
  RAB7 Primary Polyclonal Antibody
• Also known as
  RAB7 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  RAB7
• Specificity
  This is a highly specific antibody against RAB7.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  110-160/207
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RAB7
• Gene ID number
  7879
• Swiss Prot
  P51149
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  RAB7; PRO276; Ras-related protein Rab-7a; RAB7A
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  RAB7  
• Gene symbol
  RAB7A
• Short name
  Anti-RAB7
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  RAB7 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9788
• Gene
  RAB7A
• Long gene name
  RAB7A, member RAS oncogene family
• Synonyms gene
  • RAB7
  • CMT2B
• Synonyms gene name
  • RAB7, member RAS oncogene family
  • Charcot-Marie-Tooth neuropathy 2B
• GenBank acession
  • X93499
• Locus
  3q21.3
• Discovery year
  1999-03-24
• Entrez gene record
  7879
• Pubmed identfication
  • 9126495
  • 9428630
  • 12545426
• Classification
  • RAB, member RAS oncogene GTPases
• VEGA ID
  OTTHUMG00000159812
• Locus Specific Databases
  • LRG_266

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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