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PTP1B Antibody Conjugated

PTP1B Antibody Conjugated is available 7 times from Bioss primary conjugated antibodies labs

bs-0182R-Biotin | PTP1B Antibody, Biotin Conjugated size: 0.1ml | 383.12 USD

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bs-0182R-Cy3 | PTP1B Antibody, Cy3 Conjugated size: 0.1ml | 402.68 USD

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bs-0182R-Cy5 | PTP1B Antibody, Cy5 Conjugated size: 0.1ml | 402.68 USD

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bs-0182R-Cy5.5 | PTP1B Antibody, Cy5.5 Conjugated size: 0.1ml | 402.68 USD

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bs-0182R-Cy7 | PTP1B Antibody, Cy7 Conjugated size: 0.1ml | 402.68 USD

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bs-0182R-FITC | PTP1B Antibody, FITC Conjugated size: 0.1ml | 383.12 USD

Long name PTP1B Polyclonal Antibody, FITC Conjugated
Conjugation FITC
Tested applications IF(IHC-P)
Recommended dilutions IF(IHC-P)(1:50-200)
Storage conditions Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
Excitation Emission 494nm/518nm
Properties If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes.
Additional conjugation Anti-FITC Antibody
French translation anticorps
Short name PTP1B Antibody, FITC Conjugated
Technique Antibody, antibodies against human proteins, antibodies for, antibody Conjugates, Fluorescein
Label FITC
Alternative name PTP1B (Antibody to), fluorecein coupled
1. Gene info
Identity9642
GenePTPN1
Long gene name protein tyrosine phosphatase, non-receptor type 1
Synonyms gene
Discovery year 1991-09-13
Entrez gene record5770
Pubmed identfication
Classification
  • Protein tyrosine phosphatases, non-receptor type
Havana BLAST/BLATOTTHUMG00000032729
MeSH Data
Concept
Scope note:Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Tree numbers
  • E01.370.225.500.607.512.240
  • E01.370.225.750.551.512.240
  • E05.200.500.607.512.240
  • E05.200.750.551.512.240
  • E05.478.583.375
Additional information
PubMedProtein tyrosine phosphatase-1B regulates receptor tyrosine kinase signaling.
We show that PIAS1, which functions as a small ubiquitin-like modifier (SUMO) E3 ligase, associates with PTP1B in mammalian fibroblasts and catalyses sumoylation of PTP1B.
Liver PTP1B plays an important role in glucose and lipid metabolism, independent of alterations in adiposity; inhibition of PTP1B in peripheral tissues may be useful for the treatment of metabolic syndrome.
Fully differentiated PTP1B(-/-) brown adipocytes were resistant to tumor necrosis factor (TNFalpha)-induced apoptosis.
These data show that PTP1B in proopiomelanocortin neurons plays a role in short-term cold-induced reduction of spontaneous physical activity
Data suggest that PTP1B is important component in regulation of energy balance by pro-opiomelanocortin-positive neurons in the hindbrain. PTP1B knockout mice are hypersensitive to administration of leptin (or appetite depressants) to the hindbrain.
Fumosorinone increased glucose uptake and improved insulin resistance by down-regulating the expression of PTP1B and activating the insulin signaling pathway, suggesting that it may possess antidiabetic properties.
POMC-Ptp1b deletion increases plasma TNF-alpha levels
PTP1B/RNF213/alpha-KGDD pathway is critical for survival of HER2(+) breast cancer, and possibly other malignancies, in the hypoxic tumour microenvironment
Taken together, the data presented here suggest that PTP1B is essential for proper differentiation of ES cells into cardiomyocytes.
WikiPathWaysInsulin Signaling

bs-0182R-HRP | PTP1B Antibody, HRP Conjugated size: 0.1ml | 402.68 USD

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Category Conjugated Primary Antibodies
Host Organism Rabbit (Oryctolagus cuniculus)
Target Antigen PTP1B
Specificity This is a highly specific antibody against PTP1B.
Modification Unmodified
Modification site None
Clonality Polyclonal
Clone Polyclonal antibody
Concentration 1ug per 1ul
Immunogen_range 13-65/435
Subcellular location Cytoplasm
Source KLH conjugated synthetic peptide derived from human PTP-1B
Gene ID number 5770
Swiss Prot P18031
Crossreactivity Human, Mouse, Rat
Crossreactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Antigen background Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
Purification method This antibody was purified via Protein A.
Synonyms PTP1B; Tyrosine-protein phosphatase non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP-1B; PTPN1
Gene targetPTP1B Conjugated
Alternative technique antibodies
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